INT255271

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.48
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc17a7) transmembrane transport (Slc17a7)
Anatomy Link Frequency
mossy fiber 2
Slc17a7 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 15 97.12 Very High Very High Very High
Neuropathic pain 15 90.96 High High
Spinal cord 21 88.00 High High
GABAergic 51 85.84 High High
Hippocampus 28 84.88 Quite High
Glutamate 112 83.92 Quite High
Thalamus 25 80.88 Quite High
Pain 18 75.48 Quite High
cerebral cortex 6 69.64 Quite High
medulla 15 64.48 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 97 99.18 Very High Very High Very High
Nociception 12 97.90 Very High Very High Very High
Inflammatory Pain 6 97.12 Very High Very High Very High
Neuropathic Pain 24 90.96 High High
Pain 18 75.48 Quite High
Nervous System Injury 12 47.04 Quite Low
Injury 15 40.80 Quite Low
Disease 30 26.88 Quite Low
Schizophrenia 27 7.56 Low Low
Motor Neuron Diseases 42 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute nociception was unchanged in Vglut2+/- mice, which indicates that the glutamatergic signalling in the nociceptive pathway is independent of VGLUT2, unaffected by the 50% decrease in VGLUT2 levels, or compensated by an increased peripheral VGLUT1 expression.
Positive_regulation (increased) of Gene_expression (expression) of VGLUT1 associated with nociception
1) Confidence 0.59 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.90 Pain Relevance 0.68
Interestingly, this complete knockout of VGLUT2 was not compensated for by an increase in VGLUT1 levels, also shown by Western blot analysis.
Positive_regulation (increase) of Gene_expression (levels) of VGLUT1 associated with targeted disruption
2) Confidence 0.49 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.41 Pain Relevance 0.16
The Vglut1-/- mice survived 2 weeks after birth, but as the VGLUT1 expression increased during the third postnatal week in the wild-type animals, the Vglut1-/- mice started to die.
Positive_regulation (increased) of Gene_expression (expression) of VGLUT1
3) Confidence 0.49 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.10 Pain Relevance 0.23
The negative control was obtained by measuring the percentage of GFP area in the granular layer (Golgi axon) that overlapped with VGluT1 in the rosette (mossy fiber terminal).
Positive_regulation (overlapped) of Gene_expression (overlapped) of VGluT1 in mossy fiber
4) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0 Pain Relevance 0
Our results, summarized in Table 1, demonstrate that a relatively high level of VGAT transcripts was detected in the absence of a VGLUT1 signal in GFPpos samples, and conversely, a similarly high level of expression of VGLUT1 was determined for GFPneg cells in which VGAT RNA was undetectable.
Positive_regulation (level) of Gene_expression (expression) of VGLUT1
5) Confidence 0.28 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0.08 Pain Relevance 0.13

General Comments

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