INT255281

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.85
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Napb) vesicle-mediated transport (Napb)
Anatomy Link Frequency
vesicles 1
Napb (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 68 99.26 Very High Very High Very High
Glutamate receptor 2 97.68 Very High Very High Very High
Action potential 12 95.32 Very High Very High Very High
Neurotransmitter 16 88.24 High High
addiction 2 81.28 Quite High
antidepressant 26 75.76 Quite High
Pyramidal cell 18 68.36 Quite High
GABAergic 45 50.00 Quite Low
gABA 11 5.00 Very Low Very Low Very Low
Calcium channel 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 109 98.86 Very High Very High Very High
Disease 4 61.72 Quite High
Schizophrenia 1 54.76 Quite High
Suicidal Behaviour 1 54.20 Quite High
Urological Neuroanatomy 6 53.76 Quite High
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This core heteromeric protein assembly, comprised of the t-SNAREs syntaxin 1, and SNAP-25 situated at the target or plasma membrane and the v-SNARE VAMP-2/synaptobrevin on secreting vesicles, is responsible for membrane fusion that underlies the Ca2+-triggered neuroexocytosis that is required for AP-dependent neurotransmission signaling point-to-point communication between neurons, as well as the regulated secretion from neuroendocrine cells.
Localization (secreting) of SNARE in vesicles associated with action potential
1) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.15
Thus, the data indicate that the effects of stress are two-sided: stress increases glutamate release by increasing the number of SNARE complexes and the probability of release, and also affects the kinetic properties of postsynaptic glutamate receptors.
Localization (release) of SNARE associated with stress, glutamate and glutamate receptor
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.85 Pain Relevance 0.39

General Comments

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