INT255307

Context Info Confidence 0.14 First Reported 2008 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 0.12 Pain Relevance 3.05

mitochondrion (Mgst1) endoplasmic reticulum (Mgst1) nucleus (Mgst1)

Mgst1 (Mus musculus)

Pain Link Frequency Relevance Heat Nav1.2 264 100.00 sodium channel 186 85.44 depression 3 56.16 Eae 8 53.84 antidepressant 10 48.24 Central nervous system 3 37.68 Nav1.6 6 35.48 Nav1.1 3 34.88 Glutamate 24 15.16 potassium channel 21 5.00

Disease Link Frequency Relevance Heat Stroke 4 68.80 Depression 3 56.16 Manic Depressive Disorder 1 29.92 Cancer 2 29.08 Diabetes Mellitus 2 28.24 Neurological Disease 4 10.48 Anxiety Disorder 23 5.00 Apoptosis 19 5.00 Adhesions 12 5.00 Targeted Disruption 11 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Conceivably, the robust GST-TrkB phosphorylation might result from the intramolecular reaction in the stabilized conformation by the 3 chemicals mentioned above.

Phosphorylation (phosphorylation) of GST

1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.12 Pain Relevance 0.06

, whereas GST alone, although expressed at much greater levels, was not phosphorylated under equivalent conditions (Fig. 1A).

Neg (not) Phosphorylation (phosphorylated) of GST

2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0

The respective abrogation of S1112, S1123, or S1124 did not affect in vitro phosphorylation of GST-Nav1.2 1,080–1,203 by CK2 (Fig. 3 C).

Phosphorylation (phosphorylation) of GST associated with nav1.2

3) Confidence 0.02 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 1.02

The double mutation (S1124-26A) and the triple mutation (S1112-24-26A) impaired GST-Nav1.2 1,080–1,203 phosphorylation (Fig. 3 C).

Phosphorylation (phosphorylation) of GST associated with nav1.2

4) Confidence 0.02 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.94

We first determined whether the ankyrin-binding motif of Nav1.2 is phosphorylated by CK2 by conducting in vitro phosphorylation assays with GST proteins fused either to the linker II-III of Nav1.2 (Nav1.2 II-III) or truncated mutants (Fig. 3 A).

Phosphorylation (phosphorylation) of GST associated with nav1.2

5) Confidence 0.02 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 1.04

General Comments

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