INT255307

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.12
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mgst1) endoplasmic reticulum (Mgst1) nucleus (Mgst1)
Mgst1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.2 264 100.00 Very High Very High Very High
sodium channel 186 85.44 High High
depression 3 56.16 Quite High
Eae 8 53.84 Quite High
antidepressant 10 48.24 Quite Low
Central nervous system 3 37.68 Quite Low
Nav1.6 6 35.48 Quite Low
Nav1.1 3 34.88 Quite Low
Glutamate 24 15.16 Low Low
potassium channel 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 4 68.80 Quite High
Depression 3 56.16 Quite High
Manic Depressive Disorder 1 29.92 Quite Low
Cancer 2 29.08 Quite Low
Diabetes Mellitus 2 28.24 Quite Low
Neurological Disease 4 10.48 Low Low
Anxiety Disorder 23 5.00 Very Low Very Low Very Low
Apoptosis 19 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low
Targeted Disruption 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conceivably, the robust GST-TrkB phosphorylation might result from the intramolecular reaction in the stabilized conformation by the 3 chemicals mentioned above.
Phosphorylation (phosphorylation) of GST
1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.12 Pain Relevance 0.06
, whereas GST alone, although expressed at much greater levels, was not phosphorylated under equivalent conditions (Fig. 1A).
Neg (not) Phosphorylation (phosphorylated) of GST
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0
The respective abrogation of S1112, S1123, or S1124 did not affect in vitro phosphorylation of GST-Nav1.2 1,080–1,203 by CK2 (Fig. 3 C).
Phosphorylation (phosphorylation) of GST associated with nav1.2
3) Confidence 0.02 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 1.02
The double mutation (S1124-26A) and the triple mutation (S1112-24-26A) impaired GST-Nav1.2 1,080–1,203 phosphorylation (Fig. 3 C).
Phosphorylation (phosphorylation) of GST associated with nav1.2
4) Confidence 0.02 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.94
We first determined whether the ankyrin-binding motif of Nav1.2 is phosphorylated by CK2 by conducting in vitro phosphorylation assays with GST proteins fused either to the linker II-III of Nav1.2 (Nav1.2 II-III) or truncated mutants (Fig. 3 A).
Phosphorylation (phosphorylation) of GST associated with nav1.2
5) Confidence 0.02 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 1.04

General Comments

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