INT255313

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.83
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nodes 2
AIS (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 62 99.26 Very High Very High Very High
imagery 14 95.20 Very High Very High Very High
cva 48 85.68 High High
Nav1.2 88 75.44 Quite High
cytokine 2 54.80 Quite High
potassium channel 7 25.64 Quite Low
aspirin 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
Migraine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intracranial Sinus Thrombosis 40 98.94 Very High Very High Very High
Stroke 126 97.42 Very High Very High Very High
Homocystinuria 4 95.84 Very High Very High Very High
Thrombophilia 2 94.40 High High
Down Syndrome 4 93.92 High High
Infection 14 93.84 High High
Dyslipidemia /

Combined Dyslipidemia

2 93.36 High High
Hypertension 14 92.92 High High
Anaemia 10 92.36 High High
Herpes Zoster 4 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the view of our findings, it is tempting to propose that CK2 regulates sodium channel interaction with ankyrin G and thus contributes to their specific accumulation at the AIS and the nodes of Ranvier.
Positive_regulation (contributes) of Positive_regulation (accumulation) of AIS in nodes associated with sodium channel
1) Confidence 0.04 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.39
Approximately half the children presenting with AIS have a predisposing cause14 (symptomatic AIS) (fig 3), while the remainder were previously well (cryptogenic AIS); around 80% of both groups have abnormal arterial imaging.14 Intermediate risk factors include infections, hypertension, anaemia (including iron deficiency),14 25 hyperhomocysteinaemia26 and dyslipidaemias including elevated lipoprotein(a).27 Thrombophilias such as protein C deficiency, anticardiolipin antibodies and the factor V Leiden and prothrombin 20210 mutations are more frequent in ischaemic stroke populations than in controls27 but may be more commonly associated with VST rather than AIS,14 16 17 although some appear to be independent risk factors for recurrent cryptogenic AIS.22 23
Neg (independent) Positive_regulation (independent) of Positive_regulation (cryptogenic) of AIS associated with intracranial sinus thrombosis, anaemia, stroke, thrombophilia, hypertension, imagery and infection
2) Confidence 0.03 Published 2008 Journal Archives of Disease in Childhood Section Body Doc Link PMC2677268 Disease Relevance 1.80 Pain Relevance 0.12
Approximately half the children presenting with AIS have a predisposing cause14 (symptomatic AIS) (fig 3), while the remainder were previously well (cryptogenic AIS); around 80% of both groups have abnormal arterial imaging.14 Intermediate risk factors include infections, hypertension, anaemia (including iron deficiency),14 25 hyperhomocysteinaemia26 and dyslipidaemias including elevated lipoprotein(a).27 Thrombophilias such as protein C deficiency, anticardiolipin antibodies and the factor V Leiden and prothrombin 20210 mutations are more frequent in ischaemic stroke populations than in controls27 but may be more commonly associated with VST rather than AIS,14 16 17 although some appear to be independent risk factors for recurrent cryptogenic AIS.22 23
Positive_regulation (cause14) of Positive_regulation (symptomatic) of AIS associated with intracranial sinus thrombosis, anaemia, stroke, thrombophilia, hypertension, imagery and infection
3) Confidence 0.03 Published 2008 Journal Archives of Disease in Childhood Section Body Doc Link PMC2677268 Disease Relevance 1.84 Pain Relevance 0.05

General Comments

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