INT255317

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Dpep1) plasma membrane (Dpep1)
Dpep1 (Mus musculus)
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nav1.2 264 100.00 Very High Very High Very High
Glutamate 18 97.76 Very High Very High Very High
sodium channel 186 97.08 Very High Very High Very High
potassium channel 21 56.32 Quite High
Hippocampus 12 5.00 Very Low Very Low Very Low
Peripheral nervous system 9 5.00 Very Low Very Low Very Low
Nav1.6 6 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
Sciatic nerve 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 12 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of phosphorylation, immobilized GST-Nav1.2 1,080–1,203 E1111A failed to recruit MBD-ank (Fig. 3 F).
MBD Binding (recruit) of Nav1 associated with nav1.2
1) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.80
Using the surface plasmon resonance (SPR) method (Wilson, 2002; Rich and Myszka, 2007), we directly demonstrated that CK2-mediated phosphorylation regulates the interaction between the Nav1 ankyrin-binding motif and the MBD of axonal ankyrins.
MBD Binding (interaction) of Nav1
2) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.89
SPR analysis revealed that the Nav1.2 E1111A mutation totally abolished basal MBD-ank binding in the micromolar range measured in the absence of CK2 phosphorylation (Fig. 4).
MBD Binding (binding) of Nav1 associated with nav1.2
3) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.73

General Comments

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