INT255318

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dpep1, Nrcam) peptidase activity (Dpep1) cell adhesion (Nrcam)
Dpep1 (Mus musculus)
Nrcam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 186 100.00 Very High Very High Very High
Nav1.2 264 96.96 Very High Very High Very High
Glutamate 18 84.92 Quite High
potassium channel 21 56.32 Quite High
Central nervous system 3 53.84 Quite High
Nav1.6 6 51.64 Quite High
Nav1.1 3 51.04 Quite High
Hippocampus 12 5.00 Very Low Very Low Very Low
Peripheral nervous system 9 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 12 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ankyrin-binding motif of sodium channels directly interacts with a highly conserved domain in ankyrin G and B called the MBD (Srinivasan et al., 1992; Lemaillet et al., 2003; Mohler et al., 2004).
MBD Binding (interacts) of ankyrin-binding associated with sodium channel
1) Confidence 0.00 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 1.05
Using the surface plasmon resonance (SPR) method (Wilson, 2002; Rich and Myszka, 2007), we directly demonstrated that CK2-mediated phosphorylation regulates the interaction between the Nav1 ankyrin-binding motif and the MBD of axonal ankyrins.
MBD Binding (interaction) of ankyrin-binding
2) Confidence 0.00 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.89
In addition, we provide here the first evidence that the interaction between the ankyrin-binding motif and the MBD of ankyrins is regulated by CK2.
MBD Binding (interaction) of ankyrin-binding
3) Confidence 0.00 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.22

General Comments

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