INT255389

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.67
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (SREBF2) Golgi apparatus (SREBF2) endoplasmic reticulum (SREBF2)
nucleus (SREBF2) lipid metabolic process (SREBF2) cytoplasm (SREBF2)
SREBF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 17 88.40 High High
agonist 33 50.00 Quite Low
COX2 1 48.28 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 4 93.12 High High
Necrosis 48 84.48 Quite High
Lung Cancer 1 83.24 Quite High
Hyperlipidemia 1 79.24 Quite High
Breast Cancer 8 75.32 Quite High
Apoptosis 18 73.44 Quite High
Alcohol Addiction 5 71.84 Quite High
Shock 4 69.72 Quite High
Aseptic Necrosis Of Bone 4 68.64 Quite High
Bladder Cancer 2 66.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its protein product, SREBP-2, regulates several genes for sterol homeostasis by recognizing the cholesterol levels in the cell, and generally producing negative feedback [28].
Gene_expression (product) of SREBP-2
1) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2600781 Disease Relevance 0.97 Pain Relevance 0.08
shRNA expression vectors for 7 genes (IGF2R, SREBF2, AKAP11, TFAP2A, LHX3, TPX2 and ING1) were prepared as described [15].
Gene_expression (expression) of SREBF2
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958829 Disease Relevance 0.17 Pain Relevance 0
Other studies have shown a down-regulation of SREBP-2, a gene encoding the sterol regulatory element-binding protein-2 that mediates cholesterol synthesis, as well as the two SREBP-2 target genes, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) and low density lipoprotein receptor (LDLR), in HepG2 cells exposed to 30??
Gene_expression (synthesis) of SREBP-2
3) Confidence 0.17 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.53 Pain Relevance 0

General Comments

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