INT255408

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.71
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Pymr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 5 48.60 Quite Low
Inflammation 14 11.92 Low Low
cva 5 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 61 99.96 Very High Very High Very High
Schistosomiasis 21 99.70 Very High Very High Very High
Malaria 33 99.30 Very High Very High Very High
Falciparum Malaria 1 92.20 High High
Apoptosis 132 91.32 High High
Stress 3 83.92 Quite High
Helminth Infection 62 78.52 Quite High
Death 35 75.44 Quite High
Injury 12 65.00 Quite High
Disease 22 60.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since large parts of Africa are co-endemic for malaria and schistosomiasis [22] and both Plasmodium and Schistosoma parasites degrade hemoglobin, a putative target for several antimalarial drugs, we were motivated to test other antimalarials that are commonly employed in combination with an artemisinin derivative for their potential antischistosomal activities.
Protein_catabolism (degrade) of Plasmodium associated with malaria and schistosomiasis
1) Confidence 0.06 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2600813 Disease Relevance 0.81 Pain Relevance 0
During that stage of the infection, Plasmodium degrades huge quantities of haemoglobin to produce heme and haemozoin which are deleterious.
Protein_catabolism (degrades) of Plasmodium associated with infection
2) Confidence 0.01 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 0.90 Pain Relevance 0

General Comments

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