INT255461

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.30
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avpr1a) plasma membrane (Avpr1a) response to stress (Avpr1a)
signal transducer activity (Avpr1a)
Anatomy Link Frequency
blood 1
hypothalamus 1
Avpr1a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 98.72 Very High Very High Very High
Serotonin 20 90.28 High High
antagonist 56 88.72 High High
fluoxetine 124 85.80 High High
imagery 122 65.80 Quite High
sSRI 20 51.84 Quite High
Glutamate receptor 2 42.56 Quite Low
Potency 2 40.32 Quite Low
depression 8 39.28 Quite Low
Somatosensory cortex 14 32.40 Quite Low
Disease Link Frequency Relevance Heat
Aggression 186 99.78 Very High Very High Very High
Increased Venous Pressure Under Development 8 98.16 Very High Very High Very High
Embryonal Carcinoma 46 93.44 High High
Anxiety Disorder 18 56.16 Quite High
Infarction 2 48.00 Quite Low
Stress 18 45.20 Quite Low
Depression 8 39.28 Quite Low
Reprotox - General 2 2 36.48 Quite Low
Shock 2 29.12 Quite Low
Cognitive Disorder 8 28.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhanced aggression caused by activation of V1a receptors in the hypothalamus is suppressed by the simultaneous activation of 5-HT1a receptors in the same site [174].
Positive_regulation (activation) of V1a in hypothalamus associated with aggression
1) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.72 Pain Relevance 0.49
Activation of V1a receptors on vascular smooth muscle promotes vasoconstriction and can alter blood flow.
Positive_regulation (Activation) of V1a in blood associated with increased venous pressure under development
2) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.40 Pain Relevance 0.31
This was significantly reduced in cells subjected for the both siRNA treatments (OTR - Fig. 3H, respectively V1aR - Fig. 3J).
Positive_regulation (respectively) of V1aR
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.18 Pain Relevance 0.11
These 3-D models of activated OTR (OTR Gq11) and human vasopressin V1aR were described previously [38].
Positive_regulation (activated) of V1aR
4) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0 Pain Relevance 0

General Comments

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