INT255462

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.41
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avpr1a) plasma membrane (Avpr1a) response to stress (Avpr1a)
signal transducer activity (Avpr1a)
Anatomy Link Frequency
hypothalamus 1
forebrain 1
cortex 1
neural 1
Avpr1a (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 119 97.82 Very High Very High Very High
amygdala 65 97.48 Very High Very High Very High
Hippocampus 81 94.56 High High
Dismenorea 2 94.00 High High
Inflammation 2 91.16 High High
cocaine 8 87.48 High High
Neuropeptide 12 82.04 Quite High
Ventral tegmentum 27 79.40 Quite High
Substantia nigra 30 75.52 Quite High
agonist 32 71.52 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 128 99.40 Very High Very High Very High
Targeted Disruption 11 95.68 Very High Very High Very High
Myocardial Infarction 2 95.60 Very High Very High Very High
Pre-term Labor 3 94.24 High High
Dysmenorrhea 2 94.00 High High
INFLAMMATION 2 91.16 High High
Aggression 372 84.96 Quite High
Increased Venous Pressure Under Development 14 83.28 Quite High
Embryonal Carcinoma 46 76.40 Quite High
Depression 37 71.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, V1a binding is localized to the lateral hypothalamus, BNST, corticomedial amygdala, prelimbic cortex, forebrain cortex, PVN, ventral pallidum, and hippocampus.
V1a Binding (binding) of in forebrain associated with hippocampus and amygdala
1) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.12 Pain Relevance 0.29
The development of dominant/subordinate relationships in hamsters causes a reduction in vasopressin levels in the hypothalamus in submissive partners [94] while dominant partners show higher levels of V1a binding in the hypothalamus [95].
V1a Binding (binding) of in hypothalamus
2) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.41 Pain Relevance 0.08
Several groups independently reported an association of the V1a receptor with anxiety-related behavior.
V1a Binding (association) of associated with anxiety disorder
3) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.77 Pain Relevance 0.07
Vasopressin V1a receptor binding is found throughout the brain of multiple species, particularly in many areas that constitute the putative neural circuit of aggressive motivation identified with fMRI [99-103].
V1a Binding (binding) of in neural
4) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.07 Pain Relevance 0.25
Atosiban is a peptidic antagonist, but as we shall discuss below, its effects are complex, not entirely specific to oxytocin receptors (i.e., affinity for the AVP receptor subtype V1a) and the peptide is quickly metabolized.
V1a Binding (affinity) of associated with antagonist
5) Confidence 0.35 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.18 Pain Relevance 0.46
Specifically, V1a binding is localized to the lateral hypothalamus, BNST, corticomedial amygdala, prelimbic cortex, forebrain cortex, PVN, ventral pallidum, and hippocampus.
V1a Binding (binding) of in cortex associated with hippocampus and amygdala
6) Confidence 0.16 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.12 Pain Relevance 0.29
V1aR siRNA duplexes (sense, 5?
V1aR Binding (duplexes) of
7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.13 Pain Relevance 0
The clinical application of OT-GKR in this pathology could be safe because of the specific interaction with OTR and V1aR, as described in the present study.
V1aR Binding (interaction) of
8) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.62 Pain Relevance 0.17

General Comments

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