INT255568

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 8.23
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gk) histone binding (Gk) nucleus (Gk)
carbohydrate metabolic process (Gk) cytoplasm (Gk)
Anatomy Link Frequency
pancreas 4
heart 2
Gk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 56 90.08 High High
tolerance 4 16.28 Low Low
anesthesia 14 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Perioperative pain 4 5.00 Very Low Very Low Very Low
Catecholamine 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Buprenorphine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 442 100.00 Very High Very High Very High
Myocardial Infarction 312 99.98 Very High Very High Very High
Adrenal Insufficiency 4 94.64 High High
Stress 40 93.80 High High
Fibrosis 48 90.08 High High
Apoptosis 204 89.04 High High
Hypertrophy 56 88.60 High High
Muscular Dystrophy 17 87.60 High High
Sprains And Strains 12 83.96 Quite High
Coronary Heart Disease 41 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that MI increased myocardial PTEN protein expression in GK but not in Wistar rats (Figure 5A).
Positive_regulation (increased) of Gene_expression (expression) of GK associated with myocardial infarction
1) Confidence 0.17 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.05 Pain Relevance 0.03
Secondly, our results showed that Sirt1 protein was overexpressed in the myocardial tissue of GK rats and that one of the key Sirt1- targets; p53 was deacetylated in the diabetic heart compared to the non-diabetic situation.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of GK in heart associated with diabetes mellitus
2) Confidence 0.15 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.78 Pain Relevance 0.09
Increased p38 MAP kinase phosphorylation in diabetic GK rats after MI
Positive_regulation (Increased) of Gene_expression (rats) of GK associated with diabetes mellitus and myocardial infarction
3) Confidence 0.15 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.35 Pain Relevance 0
Western blotting showed an increase in Sirt1 protein expression in sham-operated GK rats compared to Wistar with no further increase in Sirt1 protein expression after MI (Figure 6A).
Positive_regulation (operated) of Gene_expression (rats) of GK associated with myocardial infarction
4) Confidence 0.15 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.40 Pain Relevance 0
In a similar fashion, INS-producing cells in the pancreas of GK rats also contained OX1R (Fig. 2c).
Positive_regulation (pancreas) of Gene_expression (rats) of GK in pancreas
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 0.86 Pain Relevance 0
The expression of OX1R in the pancreas of GK rats was higher than those in the pancreas of normal Wistar rat but similar to that seen in the pancreas of diabetic Wistar rats.
Positive_regulation (pancreas) of Gene_expression (rats) of GK in pancreas associated with diabetes mellitus
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 0.60 Pain Relevance 0
We report a girl with a de novo deletion at Xp21.2 on the maternal chromosome, including DAX1, the GK gene and 3?
Positive_regulation (including) of Gene_expression (gene) of GK
7) Confidence 0.04 Published 2008 Journal Journal of Medical Genetics Section Abstract Doc Link PMC2602739 Disease Relevance 0.18 Pain Relevance 0

General Comments

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