INT255569

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.56
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gk) histone binding (Gk) nucleus (Gk)
carbohydrate metabolic process (Gk) cytoplasm (Gk)
Anatomy Link Frequency
heart 2
blood 1
Gk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 2 91.24 High High
fibrosis 28 50.08 Quite High
anesthesia 9 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Perioperative pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 27 99.90 Very High Very High Very High
Diabetes Mellitus 191 99.80 Very High Very High Very High
Myocardial Infarction 156 98.96 Very High Very High Very High
Stress 19 95.96 Very High Very High Very High
Cv Unclassified Under Development 2 91.24 High High
Obesity 15 88.72 High High
Adrenal Insufficiency 8 85.44 High High
Coronary Artery Disease 6 81.76 Quite High
Left Ventricular Hypertrophy 2 80.04 Quite High
Muscular Dystrophy 34 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This polymorphism was also associated with a decreased insulin sensitivity in humans supporting the concept decreased insulin sensitivity may be one contributing cause of NIDDM, further linking the GK model to the human condition.
Negative_regulation (linking) of GK associated with diabetes mellitus
1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.80 Pain Relevance 0
, IRS-1 and GLUT4 protein, were impaired in the GK rat heart [39] which, at least in theory could affect the ability of the GK rat heart to respond to stress adequately.
Negative_regulation (impaired) of GK in heart associated with stress
2) Confidence 0.12 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.06 Pain Relevance 0.05
Phosphorylation of Akt kinase was decreased in GK rat hearts 12 weeks post MI compared to post-MI Wistar rats (Figure 5B).
Negative_regulation (decreased) of GK in hearts associated with myocardial infarction
3) Confidence 0.12 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.00 Pain Relevance 0.03
In response to MLP treatment, hyperglycemia was decreased significantly in the GK rats at weeks 4 and 5 (P < 0.05), but then glucose returned to levels similar to those of the controls towards the end of the 8-week experimental period.
Negative_regulation (decreased) of GK associated with hyperglycemia
4) Confidence 0.09 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2809233 Disease Relevance 0.18 Pain Relevance 0
With maltose-loading, MLE reduced peak responses of blood glucose significantly in both GK and Wistar rats (P < 0.05), supporting the inhibition of ?
Negative_regulation (reduced) of GK in blood
5) Confidence 0.09 Published 2009 Journal Nutrition Research and Practice Section Abstract Doc Link PMC2809233 Disease Relevance 0.18 Pain Relevance 0
Deletion of the DAX 1 gene can also be part of a larger contiguous deletion including the centromeric dystrophin and glycerol kinase (GK) genes.
Negative_regulation (part) of GK
6) Confidence 0.03 Published 2008 Journal Journal of Medical Genetics Section Abstract Doc Link PMC2602739 Disease Relevance 0.16 Pain Relevance 0
Deletion of the DAX 1 gene can also be part of a larger contiguous deletion including the centromeric dystrophin and glycerol kinase (GK) genes.
Negative_regulation (part) of glycerol kinase
7) Confidence 0.01 Published 2008 Journal Journal of Medical Genetics Section Abstract Doc Link PMC2602739 Disease Relevance 0.16 Pain Relevance 0

General Comments

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