INT255571

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 15.42
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gk) histone binding (Gk) nucleus (Gk)
carbohydrate metabolic process (Gk) cytoplasm (Gk)
Anatomy Link Frequency
pancreas 2
blood 1
pancreatic islets 1
aorta 1
heart 1
Gk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 16 97.40 Very High Very High Very High
fibrosis 84 90.08 High High
Pain 4 80.36 Quite High
Bioavailability 12 72.80 Quite High
anesthesia 27 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Perioperative pain 6 5.00 Very Low Very Low Very Low
Catecholamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 949 99.98 Very High Very High Very High
Myocardial Infarction 468 99.98 Very High Very High Very High
Body Weight 30 98.56 Very High Very High Very High
Hyperlipidemia 11 98.24 Very High Very High Very High
Impaired Glucose Tolerance 16 97.72 Very High Very High Very High
Obesity 37 97.56 Very High Very High Very High
Adrenal Insufficiency 8 94.64 High High
Insulin Resistance 12 94.26 High High
Stress 73 93.80 High High
Fibrosis 72 90.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that MI increased myocardial PTEN protein expression in GK but not in Wistar rats (Figure 5A).
Gene_expression (expression) of GK associated with myocardial infarction
1) Confidence 0.26 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.03 Pain Relevance 0.03
6 mol/L acetylcholine-induced relaxation of the carotid artery was significantly reduced in GK rats compared with age matched Wistar (GK; 41±7%, Wistar; 100±5%) and measurements in the aorta showed a similar trend (p?
Gene_expression (rats) of GK in aorta
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2909910 Disease Relevance 0.45 Pain Relevance 0.04
The presence NAD(P)H inhibitors including pg91ds-tat, apocynin, and diphenyleneiodonium all reduced chemiluminescence and no differences between the Wistar and GK groups were observed (Figure 4).
Gene_expression (groups) of GK
3) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.53 Pain Relevance 0.10
The phosphorylation status of Akt-regulated FOXO3a transcription factor was decreased in sham- and MI GK rats and MI Wistar rats (Figure 5C).
Gene_expression (rats) of GK associated with myocardial infarction
4) Confidence 0.19 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.69 Pain Relevance 0
Western blotting showed an increase in Sirt1 protein expression in sham-operated GK rats compared to Wistar with no further increase in Sirt1 protein expression after MI (Figure 6A).
Gene_expression (rats) of GK associated with myocardial infarction
5) Confidence 0.19 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.39 Pain Relevance 0
Western blotting from remote area confirmed the result from our earlier studies [15], that Sirt1 protein was overexpressed in GK rats.
Gene_expression (rats) of GK
6) Confidence 0.19 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 0.72 Pain Relevance 0
Secondly, our results showed that Sirt1 protein was overexpressed in the myocardial tissue of GK rats and that one of the key Sirt1- targets; p53 was deacetylated in the diabetic heart compared to the non-diabetic situation.
Gene_expression (overexpressed) of GK in heart associated with diabetes mellitus
7) Confidence 0.19 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.78 Pain Relevance 0.09
Increased p38 MAP kinase phosphorylation in diabetic GK rats after MI
Gene_expression (rats) of GK associated with diabetes mellitus and myocardial infarction
8) Confidence 0.19 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.33 Pain Relevance 0
More recently Rosengren et. al. identified a polymorphism in the GK that resulted overexpression of the ?
Gene_expression (overexpression) of GK
9) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.85 Pain Relevance 0
The GK and Wistar rats (7 weeks old) were divided into 2 groups (n=5, each) based on body weight and oral glucose tolerance tests (OGTT) were performed.
Gene_expression (divided) of GK in body associated with body weight, tolerance and impaired glucose tolerance
10) Confidence 0.14 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2809233 Disease Relevance 0.51 Pain Relevance 0.05
The pathogenesis of diabetes in the GK rat includes insulin resistance and abnormal glucose metabolism (Goto & Efendic, 1993; Janssen et al., 1999) In contrast to many other rodent models of type 2 diabetes, GK rats do not become obese and do not develop hyperlipidemia (Andallu & Varadacharyulu, 2003; Zhou et al., 1995) Accordingly, we confirmed that the GK rats showed characteristically higher FBG, insulin, HOMA-IR, glycated proteins, CRP and lower TG and FFA in the blood compared to those in Wistar rats respectively.
Gene_expression (rats) of GK in blood associated with diabetes mellitus, obesity, hyperlipidemia and insulin resistance
11) Confidence 0.14 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2809233 Disease Relevance 0.84 Pain Relevance 0
The degree of co-localization of between GLU and OX1R in GK rats (Fig. 2f) was not significantly different from that observed in Wistar normal (Figs 2d).


Gene_expression (rats) of GK
12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 0.60 Pain Relevance 0
Co-localization of OX1R with INS- and GLU in the pancreatic islets of normal and diabetic Wistar and GK rats
Gene_expression (rats) of GK in pancreatic islets associated with diabetes mellitus
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 0.65 Pain Relevance 0
The expression of OX1R in the pancreas of GK rats was higher than those in the pancreas of normal Wistar rat but similar to that seen in the pancreas of diabetic Wistar rats.
Gene_expression (rats) of GK in pancreas associated with diabetes mellitus
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 0.60 Pain Relevance 0
In a similar fashion, INS-producing cells in the pancreas of GK rats also contained OX1R (Fig. 2c).
Gene_expression (rats) of GK in pancreas
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 0.86 Pain Relevance 0
We report a girl with a de novo deletion at Xp21.2 on the maternal chromosome, including DAX1, the GK gene and 3?
Gene_expression (gene) of GK
16) Confidence 0.05 Published 2008 Journal Journal of Medical Genetics Section Abstract Doc Link PMC2602739 Disease Relevance 0.18 Pain Relevance 0
Analysis was performed using a DAX1 (NR0B1) probe (BAC RP11-1129A5), a GK probe (RP11-229K14), and a dystrophin probe (NRM52), which shares homology with exon 52 in the dystrophin gene.
Gene_expression (probe) of GK
17) Confidence 0.04 Published 2008 Journal Journal of Medical Genetics Section Body Doc Link PMC2602739 Disease Relevance 0.41 Pain Relevance 0.08

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