INT255662

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.57
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
plasma membrane (Flt1) nucleus (Flt1) kinase activity (Flt1)
Anatomy Link Frequency
hearts 2
Flt1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 5 89.28 High High
rheumatoid arthritis 57 84.48 Quite High
cva 1 81.84 Quite High
Arthritis 8 79.20 Quite High
ischemia 3 67.32 Quite High
Inflammation 23 65.36 Quite High
cytokine 2 51.48 Quite High
chemokine 2 50.96 Quite High
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 60 99.16 Very High Very High Very High
Solid Tumor 2 97.44 Very High Very High Very High
Cancer 10 96.76 Very High Very High Very High
Age-related Macular Degeneration 4 95.12 Very High Very High Very High
Hypertrophy 25 85.88 High High
Rheumatoid Arthritis 58 84.48 Quite High
Cv General 3 Under Development 1 81.84 Quite High
Hemorrhage 1 80.64 Quite High
Hypertension 1 80.24 Quite High
Arthritis 8 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other agents which target VEGF receptors, such as, chimerized anti-KDR antibody, VEGF-Trap, and a synthetic ribozyme of Flt-1, are also undergoing phase I or II trials for the treatment of solid tumors and cancer [36].
Regulation (target) of Positive_regulation (ribozyme) of Flt-1 associated with cancer and solid tumor
1) Confidence 0.29 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.46 Pain Relevance 0.37
Differential expression of isoforms of the transcription factor HIF and the subsequent induction of target genes such as VEGFR-1 and VEGFR-2 appear responsible for the response to hypoxia in hypertrophied hearts.
Spec (appear) Regulation (responsible) of Positive_regulation (induction) of VEGFR-1 in hearts associated with hypoxia
2) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 1.10 Pain Relevance 0.03

General Comments

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