INT255663

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.92
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
plasma membrane (Flt1) nucleus (Flt1) kinase activity (Flt1)
Anatomy Link Frequency
endothelial cells 2
fibroblasts 1
Flt1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 285 98.32 Very High Very High Very High
metalloproteinase 3 92.44 High High
Arthritis 40 91.60 High High
Inflammation 133 88.68 High High
Osteoarthritis 15 88.20 High High
aspirin 20 84.72 Quite High
antagonist 28 84.04 Quite High
Bioavailability 3 83.64 Quite High
cytokine 24 82.76 Quite High
Kinase C 3 72.36 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 9 100.00 Very High Very High Very High
Cancer 331 98.48 Very High Very High Very High
Rheumatoid Arthritis 290 98.32 Very High Very High Very High
Death 2 98.04 Very High Very High Very High
Hematological Disease 6 96.20 Very High Very High Very High
Arthritis 40 91.60 High High
Hyperplasia 30 91.20 High High
Metastasis 31 90.12 High High
INFLAMMATION 146 88.68 High High
Osteoarthritis 15 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Nrps can also bind to certain heparin binding isofoms of VEGF (e.g., VEGF165) to enhance the binding of VEGF to VEGFR1, and VEGFR2 (Figure 1) [31, 32].
VEGFR1 Binding (binding) of
1) Confidence 0.32 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902148 Disease Relevance 0.73 Pain Relevance 0.08
Serum samples were assayed concurrently for sFlt1, sEng and PlGF using commercially available immunoassay kits purchased from R&D Systems (Minneapolis, MN).
sFlt1 Binding (sEng) of
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 0.58 Pain Relevance 0.04
The biological functions of VEGF are mediated upon binding to receptor tyrosine kinases Vascular Endothelial Growth Factor Receptor-1, -2 (VEGFR1, 2).
VEGFR1 Binding (binding) of
3) Confidence 0.31 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902148 Disease Relevance 0.29 Pain Relevance 0.09
VEGFR1 binds VEGF with high affinity (KD ~ 10–20?
VEGFR1 Binding (binds) of
4) Confidence 0.31 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902148 Disease Relevance 0.25 Pain Relevance 0.07
This peptide selectively binds to Flt-1, and thereby, blocks the interaction between Flt-1 and VEGF or PlGF.
Flt-1 Binding (binds) of
5) Confidence 0.31 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 0.50 Pain Relevance 0.13
This same explanation was also proposed by Maynard et al. as well as reporting a significant correlation between circulating sFlt1 and placental mass in multifetal gestations (r?
sFlt1 Binding (mass) of
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 0.65 Pain Relevance 0
VEGF exerts its activity by binding to several high-affinity transmembrane endothelial cell receptors, especially VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1).
VEGFR-1 Binding (binding) of in endothelial cell
7) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.34 Pain Relevance 0.04
Second, via interaction with Flt-1, VEGF165 may directly stimulate the productions of cytochemokines, such as TNF-?
Flt-1 Binding (interaction) of
8) Confidence 0.24 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.30 Pain Relevance 0.52
This peptide selectively binds to Flt-1, and thereby, blocks the interaction between Flt-1 and VEGF or PlGF.
Flt-1 Binding (interaction) of
9) Confidence 0.24 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 0.50 Pain Relevance 0.13
As a specific ligand for Flt-1, PlGF has potent angiogenic properties, and it also induces the growth and migration of endothelial cells [24, 25].
Flt-1 Binding (ligand) of in endothelial cells
10) Confidence 0.23 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 0.60 Pain Relevance 0.20
VEGF165 exerts its biological effects by binding with its receptor subtypes, that is, fms-like tyrosine kinase (Flt-1), kinase insert domain-containing receptor (KDR) and neuropilin-1 (NP-1) [3].
Flt-1 Binding (binding) of associated with fibromyalgia
11) Confidence 0.20 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.13 Pain Relevance 0.34
Seetharam et al. demonstrated a high binding affinity of VEGFR-1 to VEGF without generating a mitogenic response in transfected NIH3T3 fibroblasts that over-expressed VEGFR-1 [35].
VEGFR-1 Binding (binding) of in fibroblasts
12) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 0.05 Pain Relevance 0

General Comments

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