INT255664

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.67
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
plasma membrane (Flt1) nucleus (Flt1) kinase activity (Flt1)
Anatomy Link Frequency
capillary 2
Flt1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 1 89.28 High High
ischemia 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 60 100.00 Very High Very High Very High
Cyanosis 8 99.18 Very High Very High Very High
Hypertrophy 25 98.40 Very High Very High Very High
Adult Respiratory Distress Syndrome 28 97.92 Very High Very High Very High
Coronary Heart Disease 7 96.24 Very High Very High Very High
Nicotine Addiction 1 93.04 High High
Pulmonary Fibrosis 1 90.96 High High
Lung Injury 4 76.72 Quite High
Disease 7 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of soluble VEGFR-1(s-flt) have been demonstrated to contribute to these observations (23).
Regulation (contribute) of Gene_expression (levels) of s-flt
1) Confidence 0.44 Published 2010 Journal American Journal of Physiology - Lung Cellular and Molecular Physiology Section Body Doc Link PMC2886605 Disease Relevance 0.72 Pain Relevance 0.04
Hypoxia or cyanosis can be potent inducers of angiogenesis, regulating the expression of hypoxia-inducible factors (HIF), vascular endothelial growth factors (VEGF), and VEGF receptors (VEGFR-1 and 2); in contrast, pressure overload hypertrophy is often associated with impaired pro-angiogenic signaling and decreased myocardial capillary density.
Regulation (regulating) of Gene_expression (expression) of VEGFR-1 in capillary associated with hypertrophy, hypoxia and cyanosis
2) Confidence 0.16 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2603310 Disease Relevance 0.96 Pain Relevance 0

General Comments

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