INT255719

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.70
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptch1) extracellular region (Ptch1) plasma membrane (Ptch1)
Ptch1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 24 61.72 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 368 99.98 Very High Very High Very High
Toxicity 4 90.36 High High
Body Weight 20 84.48 Quite High
Necrosis 4 80.72 Quite High
Cancer 8 80.36 Quite High
Insulin Resistance 100 80.24 Quite High
Obesity 40 73.12 Quite High
Hyperglycemia 28 68.12 Quite High
Fatigue 4 45.76 Quite Low
Hyperphagia 4 44.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further investigate the effect of MES on Akt phosphorylation, we examined the phosphorylation status of Akt in vitro using HepG2 cells.
Spec (investigate) Phosphorylation (phosphorylation) of MES
1) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.95 Pain Relevance 0.03
MES increased Akt phosphorylation through PI3K in HepG2 cells
Phosphorylation (phosphorylation) of MES
2) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.08 Pain Relevance 0.03
MES enhanced the phosphorylation of IR?
Phosphorylation (phosphorylation) of MES
3) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.34 Pain Relevance 0
To confirm whether HS+MES promotes insulin receptor phosphorylation, which initiates insulin action by phosphorylating multiple intracellular substrates, we determined the phosphorylation status of IR?
Phosphorylation (phosphorylation) of MES associated with shock
4) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.33 Pain Relevance 0

General Comments

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