INT255720

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.33
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hs (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 4 85.48 High High
tolerance 24 83.24 Quite High
addiction 2 50.00 Quite Low
Pain 8 30.68 Quite Low
Inflammation 14 28.80 Quite Low
cytokine 4 14.64 Low Low
agonist 6 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 519 100.00 Very High Very High Very High
Insulin Resistance 100 98.68 Very High Very High Very High
Disease 6 96.84 Very High Very High Very High
Obesity 40 94.64 High High
Stress 23 93.64 High High
Body Weight 20 89.92 High High
Diabetes Mellitus 45 88.72 High High
Liver Cancer 2 70.36 Quite High
Fatigue 4 67.28 Quite High
Hyperphagia 4 66.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine possible adverse effects of HS+MES treatment in normal mice, we confirmed various parameters on standard diet-fed, lean mice.
Spec (possible) Regulation (effects) of HS associated with shock
1) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.60 Pain Relevance 0.04
Further investigation on the possible regulation of other signaling molecules by HS+MES may be necessary to provide deeper mechanistic insight to the effects of HS+MES.
Spec (possible) Regulation (regulation) of HS associated with shock
2) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.64 Pain Relevance 0.04
The absence of observable adverse effects of HS+MES treatment in normal mice (Fig. 7) in our study suggests its safety, although it is necessary to assess the long-term effects of this treatment.
Regulation (effects) of HS associated with shock
3) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.02 Pain Relevance 0
In this study, we assessed the effects of heat shock (HS) together with mild electrical stimulation (MES) on insulin resistance in cellular and animal models.
Regulation (effects) of HS associated with shock and insulin resistance
4) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.23 Pain Relevance 0
Consistent with well-characterized mechanisms of HS gene regulation, GSEA twice identified HSF1 as a candidate transcription factor of the HS genes (Additional File 6).
Regulation (regulation) of HS gene associated with shock
5) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.83 Pain Relevance 0

General Comments

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