INT255735

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.83
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptch1, Akt1) plasma membrane (Ptch1, Akt1) transport (Akt1)
aging (Akt1) enzyme binding (Akt1) carbohydrate metabolic process (Akt1)
Ptch1 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 24 38.76 Quite Low
Pain 8 19.60 Low Low
Inflammation 12 17.72 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 4 100.00 Very High Very High Very High
Shock 368 99.98 Very High Very High Very High
Insulin Resistance 100 99.36 Very High Very High Very High
Hyperglycemia 28 89.84 High High
Body Weight 20 61.52 Quite High
Obesity 40 50.16 Quite High
Diabetes Mellitus 44 41.72 Quite Low
Targeted Disruption 8 38.80 Quite Low
Wound Healing 4 36.08 Quite Low
Fatty Liver 4 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we observed that the Akt phosphorylation induced by MES was suppressed in the presence of PI3K inhibitors, LY294002 and wortmannin (Fig. 8F; pAkt).
MES Positive_regulation (induced) of Phosphorylation (phosphorylation) of Akt
1) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.19 Pain Relevance 0
Because insulin resistance is characterized by a marked reduction in insulin-stimulated PI3K-mediated activation of Akt, we asked whether MES could increase Akt phosphorylation and ameliorate insulin resistance.
MES Positive_regulation (increase) of Phosphorylation (phosphorylation) of Akt associated with insulin resistance
2) Confidence 0.22 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2603588 Disease Relevance 0.91 Pain Relevance 0
Our results showed that HS+MES increased the insulin-stimulated phosphorylation of Akt in HepG2 cells maintained in high-glucose medium, which we used here as an in vitro model of insulin resistance.
MES Positive_regulation (increased) of Phosphorylation (phosphorylation) of Akt associated with shock and insulin resistance
3) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.11 Pain Relevance 0
MES (5 V) with pulse duration of 0.1 ms, which did not induce cell toxicity [25], applied for 10 min to normal or high glucose-exposed cells effectively increased the insulin-stimulated phosphorylation of Akt, 1 h after treatment of cells (Fig. 8B–8D).
MES Positive_regulation (increased) of Phosphorylation (phosphorylation) of Akt associated with toxicity
4) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.62 Pain Relevance 0

General Comments

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