INT255736

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.31
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mapk8, Irs1) cytosol (Mapk8, Irs1) signal transduction (Mapk8, Irs1)
nucleus (Mapk8, Irs1) mitochondrion (Mapk8) signal transducer activity (Irs1)
Mapk8 (Mus musculus)
Irs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 4 53.20 Quite High
Inflammation 6 51.32 Quite High
tolerance 12 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 50 99.20 Very High Very High Very High
Diabetes Mellitus 22 75.32 Quite High
Shock 184 69.92 Quite High
Wound Healing 2 69.68 Quite High
Cancer 4 57.28 Quite High
Pain 4 53.20 Quite High
Fracture Healing 2 52.24 Quite High
INFLAMMATION 6 51.32 Quite High
Obesity 20 5.00 Very Low Very Low Very Low
Hyperglycemia 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies have elucidated that insulin resistance could also be attributed to the serine phosphorylation of IRS-1, which is mediated by the activity of c-Jun N-terminal kinase (JNK) [18], [19].
c-Jun N-terminal kinase Positive_regulation (mediated) of Phosphorylation (phosphorylation) of IRS-1 associated with insulin resistance
1) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.15 Pain Relevance 0.08
Further studies have elucidated that insulin resistance could also be attributed to the serine phosphorylation of IRS-1, which is mediated by the activity of c-Jun N-terminal kinase (JNK) [18], [19].
JNK Positive_regulation (mediated) of Phosphorylation (phosphorylation) of IRS-1 associated with insulin resistance
2) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.16 Pain Relevance 0.08

General Comments

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