INT255740

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.42
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pik3r1, Akt1) cytosol (Pik3r1, Akt1) signal transduction (Pik3r1, Akt1)
nucleus (Pik3r1, Akt1) plasma membrane (Pik3r1, Akt1) kinase activity (Pik3r1, Akt1)
Anatomy Link Frequency
leaflet 1
Pik3r1 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 39 99.88 Very High Very High Very High
Pyramidal cell 4 93.68 High High
Pain 6 64.08 Quite High
Inflammation 42 62.20 Quite High
Hippocampus 20 24.64 Low Low
cerebral cortex 6 23.84 Low Low
Central nervous system 28 5.88 Low Low
tolerance 30 5.00 Very Low Very Low Very Low
cytokine 28 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 82 98.76 Very High Very High Very High
Obesity 73 95.04 Very High Very High Very High
Shock 188 88.16 High High
Diabetes Mellitus 152 86.20 High High
Hyperglycemia 18 85.28 High High
Wound Healing 2 80.56 Quite High
Disease 208 71.52 Quite High
Cancer 6 68.16 Quite High
Pain 6 64.08 Quite High
Fracture Healing 2 63.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is consensus that a marked reduction in insulin-stimulated PI3K-mediated activation of Akt results in decreased insulin sensitivity in vivo [14], [15], [16], [17].
PI3K Positive_regulation (activation) of Akt
1) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.85 Pain Relevance 0.10
Because insulin resistance is characterized by a marked reduction in insulin-stimulated PI3K-mediated activation of Akt, we asked whether MES could increase Akt phosphorylation and ameliorate insulin resistance.
PI3K Positive_regulation (activation) of Akt associated with insulin resistance
2) Confidence 0.24 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2603588 Disease Relevance 0.88 Pain Relevance 0
PI3K is insulin regulated and activates protein kinase B (PKB), otherwise known as AKT.
PI3K Positive_regulation (activates) of PKB
3) Confidence 0.10 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.27 Pain Relevance 0.05
PI3K activates AKT by generating polyphosphoinositides in the inner leaflet of the plasma membrane.
PI3K Positive_regulation (activates) of AKT in leaflet
4) Confidence 0.09 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.15 Pain Relevance 0.13
PI3K is insulin regulated and activates protein kinase B (PKB), otherwise known as AKT.
PI3K Positive_regulation (activates) of protein kinase B
5) Confidence 0.08 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.27 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox