INT255780

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.28
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ACHE) extracellular space (ACHE) extracellular region (ACHE)
cell adhesion (ACHE) Golgi apparatus (ACHE) plasma membrane (ACHE)
ACHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 1 87.92 High High
Peripheral nervous system 1 81.44 Quite High
Bioavailability 6 81.36 Quite High
transdermal 2 59.36 Quite High
Hippocampus 1 55.96 Quite High
Clonidine 48 50.00 Quite Low
Opioid 2 37.64 Quite Low
Central nervous system 10 35.68 Quite Low
withdrawal 2 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 3 94.96 High High
Toxicity 4 92.20 High High
Respiratory Failure 5 87.20 High High
Hepatotoxicity 1 83.60 Quite High
Disease 10 79.32 Quite High
Poisoning 20 78.36 Quite High
Death 5 76.60 Quite High
Cognitive Disorder 1 68.52 Quite High
Vomiting 11 18.32 Low Low
Suicidal Behaviour 1 14.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oximes, such as pralidoxime, can reactivate acetylcholinesterase but the ability to reverse acetylcholinesterase (AChE) inhibition with oximes varies with the type of pesticide ingested and time to treatment as both these factors affect the rate of enzyme ageing [8,9].
Negative_regulation (reverse) of Negative_regulation (inhibition) of acetylcholinesterase associated with aging
1) Confidence 0.43 Published 2009 Journal Trials Section Body Doc Link PMC2743678 Disease Relevance 0.77 Pain Relevance 0.04
Rationale for intranasal delivery of acetylcholinesterase inhibitors
Negative_regulation (delivery) of Negative_regulation (inhibitors) of acetylcholinesterase
2) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604884 Disease Relevance 0.50 Pain Relevance 0.20

General Comments

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