INT255787

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 7.61
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Anatomy Link Frequency
neuronal 4
neurons 4
fat 2
liver 2
muscle 2
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 410 99.56 Very High Very High Very High
agonist 14 97.16 Very High Very High Very High
Acupuncture 50 94.32 High High
Inflammation 20 90.20 High High
tolerance 37 67.40 Quite High
Neuritis 4 53.92 Quite High
cOX1 5 53.04 Quite High
Multiple sclerosis 62 50.24 Quite High
ischemia 1 45.00 Quite Low
Demyelination 12 36.04 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 130 99.78 Very High Very High Very High
Targeted Disruption 7 99.78 Very High Very High Very High
Alzheimer's Dementia 9 99.76 Very High Very High Very High
Diabetes Mellitus 74 99.52 Very High Very High Very High
Insulin Resistance 131 99.44 Very High Very High Very High
Death 97 99.24 Very High Very High Very High
Disease 81 97.40 Very High Very High Very High
Motor Neuron Diseases 4 96.60 Very High Very High Very High
Metabolic Disorder 5 96.44 Very High Very High Very High
Toxicity 22 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, CR elevates SIRT1 expression in a
                       number of tissues [11], and transgenic mice that overexpress SIRT1
                       exhibit a phenotype mirroring some aspects of CR [12]. 
Positive_regulation (overexpress) of Gene_expression (overexpress) of SIRT1 associated with targeted disruption
1) Confidence 0.67 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC2837205 Disease Relevance 0.46 Pain Relevance 0.03
For example, CR elevates SIRT1 expression in a
                       number of tissues [11], and transgenic mice that overexpress SIRT1
                       exhibit a phenotype mirroring some aspects of CR [12]. 
Positive_regulation (elevates) of Gene_expression (expression) of SIRT1 associated with targeted disruption
2) Confidence 0.67 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC2837205 Disease Relevance 0.46 Pain Relevance 0.03
Several investigators have found that the anti-apoptotic effect of SIRT1 overexpression in neurons as well as non-neuronal cell types is mimicked by chemical agonists of SIRT1 and can be inhibited by pharmacological inhibitors of this sirtuin [11], [31]–[36].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SIRT1 in neurons associated with agonist and apoptosis
3) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.40 Pain Relevance 0.05
For example, the overexpression of SIRT1 prevents neuronal death in tissue culture models of Alzheimer's disease, amyotropic lateral sclerosis, and polyglutamine toxicity and reduces hippocampal degeneration in a mouse model of Alzheimer's disease toxicity [14], [20].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SIRT1 in neuronal associated with toxicity, disease, motor neuron diseases and death
4) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.76 Pain Relevance 0.05
Collectively, these studies support the possibility that EA improves insulin sensitivity, at least partially, because of increasing SIRT1/PGC-1?
Positive_regulation (increasing) of Gene_expression (/) of SIRT1 associated with electroacupuncture
5) Confidence 0.47 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.44 Pain Relevance 0.15
Specifically, low-frequency EA improved insulin sensitivity in a mouse model of genetic insulin resistance and diabetes, at least in part, via stimulation of SIRT1/PGC-1?
Positive_regulation (stimulation) of Gene_expression (/) of SIRT1 associated with diabetes mellitus, insulin resistance and electroacupuncture
6) Confidence 0.47 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.69 Pain Relevance 0.31
Meanwhile, electric stimulation such as exercise induces muscle contraction, which has been observed to activate SIRT1/PGC-1?
Positive_regulation (activate) of Gene_expression (/) of SIRT1 in muscle
7) Confidence 0.47 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.71 Pain Relevance 0.37
Moreover, overexpression of SIRT1 protects against insulin resistance in diabetic models [7] and high-fat-diet-induced metabolic disorder [8].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SIRT1 in fat associated with metabolic disorder, diabetes mellitus and insulin resistance
8) Confidence 0.44 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 1.23 Pain Relevance 0.07
The present study revealed that EA activated SIRT1, indicating that improved insulin resistance by EA may be attributed to enhanced SIRT1 expression.
Positive_regulation (enhanced) of Gene_expression (expression) of SIRT1 associated with insulin resistance and electroacupuncture
9) Confidence 0.44 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.34 Pain Relevance 0.33
Figure 4 shows that this catalytically-inactive form of SIRT1 was as protective as the wild-type form when overexpressed in neurons.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of SIRT1 in neurons
10) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.39 Pain Relevance 0.03
As shown in Fig. 1A, overexpression of SIRT1 had no effect on neuronal survival in HK, but completely inhibited LK-induced cell death.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SIRT1 in neuronal associated with death
11) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.75 Pain Relevance 0
Resveratrol, SIRT1, and amyloid pathology
Positive_regulation (Resveratrol) of Gene_expression (Resveratrol) of SIRT1 associated with alzheimer's dementia
12) Confidence 0.31 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 0.87 Pain Relevance 0.03
Direct SIRT-1-mediated deacetylation of the liver X receptor (LXR)
Positive_regulation (Direct) of Gene_expression (deacetylation) of SIRT-1-mediated in liver
13) Confidence 0.15 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.12 Pain Relevance 0.03

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