INT255788

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.39
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Aadac)
Aadac (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 94 99.54 Very High Very High Very High
Intracerebroventricular 1 53.20 Quite High
cytokine 13 51.56 Quite High
Hippocampus 5 46.64 Quite Low
ischemia 2 29.48 Quite Low
cINOD 17 5.00 Very Low Very Low Very Low
Nicotine 13 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Somatostatin 9 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 105 99.54 Very High Very High Very High
Lifespan 2 95.28 Very High Very High Very High
Disease 168 92.64 High High
Aging 8 89.52 High High
Alzheimer's Dementia 18 85.72 High High
Drug Induced Neurotoxicity 3 84.40 Quite High
Pathologic Processes 1 84.28 Quite High
Toxicity 4 76.96 Quite High
Targeted Disruption 14 48.56 Quite Low
Brain Injury 1 42.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, resveratrol binds to and activates the deacetylase activity of several sirtuin members, including the mammalian ortholog, SIRT1, by lowering the Michaelis constants of these enzymes [37].
Positive_regulation (activates) of deacetylase
1) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 0.66 Pain Relevance 0.03
Resveratrol has anti-inflammatory properties due to its activation of SIRT-1, a class III histone deacetylase; activation of SIRT-1 by resveratrol inhibited NF-?
Positive_regulation (activation) of deacetylase associated with inflammation
2) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 0.73 Pain Relevance 0.16

General Comments

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