INT255790

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.68
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Anatomy Link Frequency
spines 1
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 13 90.60 High High
gABA 7 78.00 Quite High
imagery 3 31.56 Quite Low
GABAergic 8 22.24 Low Low
cINOD 2 7.12 Low Low
depression 6 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 37 99.04 Very High Very High Very High
Targeted Disruption 6 93.40 High High
Alzheimer's Dementia 9 39.04 Quite Low
Dementia 3 33.20 Quite Low
INFLAMMATION 5 5.68 Low Low
Aids-related Complex 15 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Non-genital Cutaneous Warts 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Degradation of the extracellular matrix with the tPA/plasminogen proteolytic cascade prevents the loss of superficial spines normally induced by 4 days of MD (Mataga et al. 2004)—an effect that is not observed in tPA knockout mice. tPA application also mimics the enhancement of spine dynamics seen after brief (2 days) MD (Oray et al. 2004).
Protein_catabolism (Degradation) of tPA in spines associated with targeted disruption
1) Confidence 0.32 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.09 Pain Relevance 0.04
In addition, the t-PA-plasmin proteolytic cascade was found to promote the clearance of A?
Protein_catabolism (proteolytic) of t-PA
2) Confidence 0.05 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 0.59 Pain Relevance 0.05

General Comments

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