INT255808

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMN2) nucleoplasm (SMN2) cell death (SMN2)
mRNA processing (SMN2) RNA binding (SMN2) nucleus (SMN2)
Anatomy Link Frequency
fibroblasts 1
SMN2 (Homo sapiens)
SMN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 95.84 Very High Very High Very High
Inflammation 1 95.36 Very High Very High Very High
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinal Muscular Atrophy 8 98.12 Very High Very High Very High
INFLAMMATION 1 95.36 Very High Very High Very High
Disease 20 68.40 Quite High
Neurodegenerative Disease 5 64.28 Quite High
Tauopathy 18 54.00 Quite High
Supranuclear Palsy 15 52.08 Quite High
Motor Neuron Diseases 4 5.00 Very Low Very Low Very Low
Parkinson's Disease 3 5.00 Very Low Very Low Very Low
Frontotemporal Dementia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aclarubicin, but not adriamycin, increased the amount of full-length transcript produced by the SMN2 gene, which in turn restored SMN protein levels in fibroblasts isolated from a SMA patient.
SMN2 Positive_regulation (restored) of SMN in fibroblasts associated with spinal muscular atrophy
1) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.89 Pain Relevance 0.14

General Comments

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