INT255824

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.62
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPT) cell death (MAPT) plasma membrane (MAPT)
cytoskeleton (MAPT) enzyme binding (MAPT) cytoplasm (MAPT)
Anatomy Link Frequency
PSP 2
MAPT (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 10 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
Enkephalin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tauopathy 19 100.00 Very High Very High Very High
Disease 145 98.20 Very High Very High Very High
Parkinson's Disease 158 97.88 Very High Very High Very High
Frontotemporal Dementia 7 96.12 Very High Very High Very High
Dementia 62 95.28 Very High Very High Very High
Supranuclear Palsy 19 92.88 High High
Alzheimer's Dementia 18 87.88 High High
Cognitive Disorder 14 65.12 Quite High
Syndrome 7 40.88 Quite Low
Neurodegenerative Disease 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternative splicing of exon 10 in the tau gene as a target for treatment of tauopathies

Tau aggregation is one of the major features in Alzheimer's disease and in several other tauopathies, including frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), and progressive supranuclear palsy (PSP).

Regulation (target) of Gene_expression (aggregation) of Tau in PSP associated with parkinson's disease, tauopathy, supranuclear palsy, frontotemporal dementia and disease
1) Confidence 0.44 Published 2008 Journal BMC Neurosci Section Title Doc Link PMC2604894 Disease Relevance 0.88 Pain Relevance 0
However, significant inverse correlation between t-tau levels and MMSE (r = ?
Regulation (correlation) of Gene_expression (levels) of t-tau
2) Confidence 0.03 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.74 Pain Relevance 0

General Comments

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