INT255827

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.63
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPT) cell death (MAPT) plasma membrane (MAPT)
cytoskeleton (MAPT) enzyme binding (MAPT) cytoplasm (MAPT)
MAPT (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 17 79.76 Quite High
Eae 14 37.20 Quite Low
Hippocampus 18 23.76 Low Low
Inflammation 19 5.00 Very Low Very Low Very Low
Kinase C 18 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
cerebral cortex 7 5.00 Very Low Very Low Very Low
Pyramidal cell 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
diabetic neuropathy 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tauopathy 24 100.00 Very High Very High Very High
Neurodegenerative Disease 26 97.36 Very High Very High Very High
Disease 208 94.92 High High
Affective Disorder 1 92.48 High High
Aging 10 86.88 High High
Targeted Disruption 50 82.60 Quite High
Amyloid Plaque 23 81.52 Quite High
Disease Progression 2 79.20 Quite High
Congenital Anomalies 8 70.00 Quite High
Frontotemporal Dementia 5 65.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tauopathies and mutations in Tau
Positive_regulation (mutations) of Gene_expression (Tauopathies) of Tau associated with tauopathy
1) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.87 Pain Relevance 0.06
Impaired insulin/IGF1 signalling results in the hyperphosphorylation of Tau due to reduced activation of PI3K/AKT and increased levels of GSK-3?
Positive_regulation (increased) of Gene_expression (levels) of Tau
2) Confidence 0.49 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.04 Pain Relevance 0.04
Two questions were addressed: first, whether chronic lithium treatment is able to prevent the formation of aberrant tau aggregates (formed by overexpression of FTDP-17 tau and GSK-3?)
Positive_regulation (overexpression) of Gene_expression (overexpression) of FTDP-17
3) Confidence 0.08 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.71 Pain Relevance 0

General Comments

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