INT255833

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.03
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ribosome (SF1) nucleolus (SF1) RNA binding (SF1)
nucleus (SF1)
SF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 12 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 80 87.52 High High
Motor Neuron Diseases 16 77.40 Quite High
Tauopathy 72 32.88 Quite Low
Supranuclear Palsy 60 5.00 Very Low Very Low Very Low
Spinal Muscular Atrophy 32 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 20 5.00 Very Low Very Low Very Low
Parkinson's Disease 12 5.00 Very Low Very Low Very Low
Frontotemporal Dementia 12 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The large subunit of splicing factor U2AF binds to the polypyrimidine tract while SF1 interacts with the branch site [16].
SF1 Binding (binds) of
1) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.25 Pain Relevance 0
The large subunit of splicing factor U2AF binds to the polypyrimidine tract while SF1 interacts with the branch site [16].
SF1 Binding (interacts) of
2) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.24 Pain Relevance 0
SR proteins, on the other hand, function as trans-splicing factors that facilitate the interaction of U1 snRNP with the 5' splice site, and the assembly of spliceosomes. through interactions with U2AF [17], SF1, and other splicing factors.
SF1 Binding (interactions) of
3) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.16 Pain Relevance 0
The splicing events begin with recognition of these elements by assembly of the spliceosome, a complex consisting of different small nuclear ribonuclear particles (snRNPs; U1, U2AF65, U4/U6, and U5), SR proteins (SRP30C, SRP20, SRP40, SRP55, SC35, SF2, hTra2b1), and other factors, including SF1 [5] (reviewed by Kramer [15]).
SF1 Binding (recognition) of
4) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.38 Pain Relevance 0

General Comments

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