INT25585

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 39
Total Number 41
Disease Relevance 17.96
Pain Relevance 7.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (DNAH8) cytoskeleton (DNAH8) cilium (DNAH8)
cytoplasm (DNAH8)
Anatomy Link Frequency
red blood cells 2
lung 2
cardiac muscles 1
plasma 1
erythrocyte 1
DNAH8 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 43 100.00 Very High Very High Very High
Migraine 27 99.80 Very High Very High Very High
lidocaine 18 99.76 Very High Very High Very High
Glutamate 52 99.56 Very High Very High Very High
Enkephalin 2 99.48 Very High Very High Very High
agonist 46 99.46 Very High Very High Very High
fibrosis 44 99.20 Very High Very High Very High
ischemia 126 98.96 Very High Very High Very High
bradykinin 72 98.62 Very High Very High Very High
Serotonin 9 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Migraine With Aura 2 99.96 Very High Very High Very High
Headache 36 99.80 Very High Very High Very High
Shock 183 99.68 Very High Very High Very High
Critical Illness 27 99.36 Very High Very High Very High
Cystic Fibrosis 44 99.20 Very High Very High Very High
Cv Unclassified Under Development 125 98.96 Very High Very High Very High
Hypoxia 214 98.78 Very High Very High Very High
Heat Stress Disorders 2 98.76 Very High Very High Very High
Ganglion Cysts 76 98.40 Very High Very High Very High
Natriuresis 14 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In individuals with a predilection to fall in love there was decreased digoxin synthesis, increased membrane Na+-K+ ATPase activity, decreased tryptophan catabolites (serotonin, quinolinic acid, and nicotine), and increased tyrosine catabolites (dopamine, noradrenaline, and morphine).
Positive_regulation (increased) of ATPase associated with dopamine, nicotine, noradrenaline, serotonin and morphine
1) Confidence 0.70 Published 2003 Journal Int. J. Neurosci. Section Abstract Doc Link 12745629 Disease Relevance 0 Pain Relevance 0.33
In non-creative individuals there was decreased digoxin synthesis, increased membrane Na(+)-K+ ATPase activity, decreased tryptophan catabolites (serotonin, quinolinic acid, and nicotine), and increased tyrosine catabolites (dopamine, noradrenaline, and morphine).
Positive_regulation (increased) of ATPase associated with dopamine, nicotine, noradrenaline, serotonin and morphine
2) Confidence 0.68 Published 2003 Journal Int. J. Neurosci. Section Abstract Doc Link 12856483 Disease Relevance 0 Pain Relevance 0.60
The stimulation of the MDR1-ATPase by these agents does not correlate with their known biochemical or pharmacological activities but rather with their hydrophobicity.
Positive_regulation (stimulation) of ATPase
3) Confidence 0.49 Published 1994 Journal FASEB J. Section Abstract Doc Link 7914178 Disease Relevance 0 Pain Relevance 0.10
A1A2 Na+/K+-ATPase mutations cause familial hemiplegic migraine type 2 (FHM2).
Positive_regulation (cause) of ATPase associated with migraine with aura and migraine
4) Confidence 0.49 Published 2004 Journal Neurology Section Abstract Doc Link 15159495 Disease Relevance 0.39 Pain Relevance 0.17
The drugs behaved like uncouplers of mitochondrial respiration, decreased membrane potential, stimulated ATPase activity and had an ionophore-like effect upon calcium transport. 3.
Positive_regulation (stimulated) of ATPase
5) Confidence 0.46 Published 1989 Journal Int. J. Biochem. Section Abstract Doc Link 2533113 Disease Relevance 0.07 Pain Relevance 0.33
The amounts of PLB and sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2a) were not changed.
Neg (not) Positive_regulation (changed) of ATPase in reticulum
6) Confidence 0.45 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16582020 Disease Relevance 0.88 Pain Relevance 0.07
The observed stereoselectivity suggests effects on specific proteins, the ryanodine Ry1 receptor and the Ca2+-ATPase pump, rather than non-specific increase in Ca2+ permeability.
Positive_regulation (increase) of ATPase
7) Confidence 0.45 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15840391 Disease Relevance 0 Pain Relevance 0.06
In this report we demonstrate that various biologically active hydrophobic peptide derivatives, e.g., proteinase inhibitors, chemoattractants, ionophores, enkephalins, and immunosuppressants, stimulate a membrane ATPase activity associated with the human multidrug transporter (MDR1).
Positive_regulation (stimulate) of ATPase associated with enkephalin
8) Confidence 0.33 Published 1994 Journal FASEB J. Section Abstract Doc Link 7914178 Disease Relevance 0 Pain Relevance 0.10
Moreover, in our study, even though PBN reduced the level of conjugated dienes significantly both during hypoxia-ischemia and during reoxygenation-reperfusion, it failed to recover the activity of Na+, K+-ATPase during reoxygenation-reperfusion.
Neg (failed) Positive_regulation (recover) of ATPase associated with hypoxia and ischemia
9) Confidence 0.28 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816844 Disease Relevance 0.66 Pain Relevance 0.18
The activity of Na+, K+-ATPase is dependent on the cellular energy state, because ATP is rquired as substrate for the enzyme.
Positive_regulation (dependent) of ATPase
10) Confidence 0.28 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816844 Disease Relevance 0.87 Pain Relevance 0.20
Salicylates inhibited ATPase activity stimulated by this specific heptapeptide but did not block ATP binding or induce BiP expression.
Positive_regulation (stimulated) of ATPase
11) Confidence 0.26 Published 2001 Journal FASEB J. Section Abstract Doc Link 11689471 Disease Relevance 0.13 Pain Relevance 0.28
5 M ouabain to test whether increased Na+/K+ ATPase activity could underlie the increased thermotolerance conferred by HS pre-treatment [7]. 10?
Positive_regulation (increased) of ATPase associated with shock
12) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137934 Disease Relevance 1.97 Pain Relevance 0
The lidocaine-induced shape change occurred as a result of spectrin aggregation, which altered the intracellular environment of the human red blood cells, mediated by carbonic anhydrase and activation of vacuolar type H(+)-ATPase (V-ATPase).
Positive_regulation (activation) of ATPase in red blood cells associated with lidocaine
13) Confidence 0.10 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566145 Disease Relevance 0 Pain Relevance 0.73
The lidocaine-induced shape change occurred as a result of spectrin aggregation, which altered the intracellular environment of the human red blood cells, mediated by carbonic anhydrase and activation of vacuolar type H(+)-ATPase (V-ATPase).
Positive_regulation (activation) of ATPase in red blood cells associated with lidocaine
14) Confidence 0.10 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566145 Disease Relevance 0 Pain Relevance 0.73
This mutation maps to a domain of the protein that is not involved in direct interactions with other troponins, but it causes increased ATPase activity and Ca2+-dependent force generation [11].
Positive_regulation (increased) of ATPase
15) Confidence 0.10 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2663550 Disease Relevance 0.23 Pain Relevance 0
Given that circulating octopamine increases after heat stress in locusts [18], that octopamine reduces K+ conductances and increases activity of the Na+/K+ ATPase [19] and that HS reduces whole cell K+ currents in locust metathoracic neurons [20], we hypothesized that HS preconditioning acts by stabilizing K+ homeostasis.
Positive_regulation (increases) of ATPase in metathoracic neurons associated with shock and heat stress disorders
16) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137934 Disease Relevance 1.04 Pain Relevance 0.03
This mutation maps to a domain of the protein that is not involved in direct interactions with other troponins, but it causes increased ATPase activity and Ca2+-dependent force generation [11].
Positive_regulation (causes) of ATPase
17) Confidence 0.07 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2663550 Disease Relevance 0.23 Pain Relevance 0
stimulation of endothelial nitric oxide synthase (eNOS) and Na+,K+-ATPase

[26].

Positive_regulation (stimulation) of ATPase
18) Confidence 0.06 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2266809 Disease Relevance 0.73 Pain Relevance 0.04
Since glutamate uptake by astrocytes activates Na+K+ATPase [42,43], the associated consumption of 1 ATP was included in the corresponding equation (r75).
Positive_regulation (activates) of ATPase in astrocytes associated with glutamate
19) Confidence 0.06 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC2246127 Disease Relevance 0 Pain Relevance 0.42
In isolated congenital CFTR dysfunction (cystic fibrosis) an increase in sodium transport by an increase in apical ENaC and basolateral Na/K ATPase activity in the airways can compensate for a reduction in alveolar chloride and sodium transport.
Positive_regulation (increase) of ATPase associated with fibrosis and cystic fibrosis
20) Confidence 0.06 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 1.00 Pain Relevance 0.13

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