INT255920

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.52
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF2) nucleolus (ATF2) nucleus (ATF2)
intracellular (ATF2) DNA binding (ATF2)
ATF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 36 93.68 High High
Kinase C 3 72.88 Quite High
Inflammatory response 3 52.80 Quite High
Central nervous system 21 50.00 Quite Low
fibrosis 11 25.00 Low Low
Inflammation 24 21.60 Low Low
agonist 11 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 3 98.74 Very High Very High Very High
Insulin Resistance 25 94.48 High High
Drug Induced Neurotoxicity 2 94.16 High High
Apoptosis 76 91.60 High High
Stress 20 84.96 Quite High
Diabetes Mellitus 17 80.48 Quite High
Lung Cancer 24 79.16 Quite High
Targeted Disruption 9 60.04 Quite High
Metabolic Syndrome 23 52.84 Quite High
INFLAMMATION 25 52.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased activation of IRS-1 during hyperinsulinemia increases expression of SREBP-1c, which normally blocks IRS-2 expression and CREBP critical for hepatic gluconeogenesis.
Gene_expression (expression) of CREBP associated with hyperinsulinism
1) Confidence 0.75 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.62 Pain Relevance 0.08
Results showed a high expression of p38 MAPK (ATF-2) at 4 ?
Gene_expression (expression) of ATF-2
2) Confidence 0.12 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2864039 Disease Relevance 0.13 Pain Relevance 0
MAPK can phosphorylate a variety of transcription factors, for example, ATF2, ELK1, CREB, MEF2C, CHOP/GADD153, and C/EBP?
Gene_expression (/) of ATF2
3) Confidence 0.11 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.11 Pain Relevance 0.25
In our study, we observed an up–regulation p38 MAPK (ATF-2 substrate expression) at 4 ?
Gene_expression (expression) of ATF-2
4) Confidence 0.09 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2864039 Disease Relevance 0.66 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox