INT255949

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.28
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Dsor1)
Dsor1 (Drosophila melanogaster)
Pain Term Frequency Confidence Heat
cytokine 72 91.72 High High
Inflammatory response 4 76.96 Quite High
Central nervous system 48 50.00 Quite Low
Pain 50 50.00 Quite Low
Nerve growth factor 14 30.72 Quite Low
Spinal nerve ligature 2 5.00 Very Low Very Low Very Low
long-term potentiation 12 5.00 Very Low Very Low Very Low
Lasting pain 8 5.00 Very Low Very Low Very Low
Spinal cord 44 5.00 Very Low Very Low Very Low
Neuropathic pain 16 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Targeted Disruption 12 84.20 Quite High
INFLAMMATION 52 76.56 Quite High
Myotonic Dystrophy 8 50.00 Quite Low
Pain 52 50.00 Quite Low
Stress 10 37.44 Quite Low
Death 2 36.44 Quite Low
Necrosis 6 32.48 Quite Low
Cancer 8 32.12 Quite Low
Injury 16 29.28 Quite Low
Hyperalgesia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MAPK can phosphorylate a variety of transcription factors, for example, ATF2, ELK1, CREB, MEF2C, CHOP/GADD153, and C/EBP?
Phosphorylation (phosphorylate) of MAPK
1) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.12 Pain Relevance 0.22
MAPK, in turn, allows it to efficiently phosphorylate its protein substrates [13].
Phosphorylation (phosphorylate) of MAPK
2) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.16 Pain Relevance 0.18
In turn, MEK phosphorylates ERK at two tyrosine and threonine residues.
Phosphorylation (phosphorylates) of MEK
3) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0 Pain Relevance 0
In regard to the levels of phosphorylation of Raf and MEK, it is possible that ERK, apart from phosphorylating downstream substrates, could also phosphorylate upstream targets, such as those two kinases [13, 58, 68] generating a negative feedback dependent on hyperphosphorylation [15, 45].
Phosphorylation (phosphorylation) of MEK
4) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0 Pain Relevance 0
Serine/threonine-specific protein kinase family member Akt phosphorylated CUG-BP1 at Ser28 and increased interaction of CUG-BP1 with cyclin D1 mRNA, which is a strong promoter of cell proliferation.
Phosphorylation (phosphorylated) of kinase
5) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0

General Comments

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