INT255967

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.56
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr1) plasma membrane (Tlr1) intracellular (Tlr1)
Tlr1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 14 93.16 High High
Inflammation 20 92.76 High High
chemokine 10 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 116 96.60 Very High Very High Very High
Infection 110 95.36 Very High Very High Very High
Mycobacterial Infection 145 94.16 High High
INFLAMMATION 21 92.76 High High
Apoptosis 4 84.84 Quite High
Stress 2 79.32 Quite High
Shock 4 74.32 Quite High
Alzheimer's Dementia 11 5.00 Very Low Very Low Very Low
Granuloma 5 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
up-regulated TLRs, transcription of TLR1,TLR2,TLR3,TLR5,TLR8, and TLR10 was significantly down-regulated in similarly treated AD cells.
Transcription (transcription) of TLR1 associated with disease
1) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604897 Disease Relevance 0.88 Pain Relevance 0.09
Amongst the TLR genes, we found that mRNA transcripts for TLR 1, 2, 12 and 13, were significantly induced at day 21 (Table 2), while induction of TLR4 or TLR9 was not detected on D21 post infection.
Transcription (transcripts) of TLR 1 associated with infection
2) Confidence 0.01 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.68 Pain Relevance 0.12

General Comments

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