INT255990

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Context Info
Confidence 0.73
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.74
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn)
lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
brain 2
muscle cells 1
fat 1
Il1rn (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 60 96.80 Very High Very High Very High
Hippocampus 21 95.92 Very High Very High Very High
amygdala 4 95.40 Very High Very High Very High
Central nervous system 11 95.08 Very High Very High Very High
Inflammation 43 95.00 High High
Glutamate 5 79.64 Quite High
long-term potentiation 9 74.32 Quite High
ischemia 5 69.04 Quite High
isoflurane 1 65.88 Quite High
anesthesia 2 65.24 Quite High
Disease Link Frequency Relevance Heat
Disease 66 100.00 Very High Very High Very High
Alzheimer's Dementia 13 99.20 Very High Very High Very High
Amnesia 9 97.32 Very High Very High Very High
Sepsis 32 95.76 Very High Very High Very High
INFLAMMATION 54 95.00 High High
Cognitive Disorder 73 94.24 High High
Obesity 45 84.28 Quite High
Targeted Disruption 20 83.52 Quite High
Cv Unclassified Under Development 5 69.04 Quite High
Apoptosis 1 68.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SYBR Green detection (Power SYBR® Green PCR Master Mix, Applied Biosystems, Warrington, UK), was used for Il1rn, Il1b, Il10, and Tnf.
Localization (used) of Il1rn
1) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.08 Pain Relevance 0.17
 ; AD: Alzheimer's disease; Ang: angiotensin; FDA: Food and Drug Administration; IRAP: insulin-regulated aminopeptidase; LVV-H7: LVV-hemorphin 7.


Localization (disease) of IRAP associated with disease
2) Confidence 0.60 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.49 Pain Relevance 0
Upon stimulation by insulin in fat and muscle cells [41], IRAP translocates to the plasma membrane, presenting its catalytic domain to the extracellular surface.
Localization (translocates) of IRAP in muscle cells
3) Confidence 0.56 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.07 Pain Relevance 0.04
In support of this hypothesis, IRAP is found in high concentrations in areas of the brain that are important for memory processing, including the hippocampus, amygdala, and prefrontal cortex [22-24].


Localization (found) of IRAP in brain associated with hippocampus and amygdala
4) Confidence 0.56 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.28 Pain Relevance 0.27
As IL-1Ra is able to translocate directly into the brain [33], we are unable to discriminate whether peripheral cytokines and/or de-novo production in the CNS account for this cognitive dysfunction.
Localization (translocate) of IL-1Ra in brain associated with cognitive disorder, central nervous system and cytokine
5) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.75 Pain Relevance 0.38
Upon stimulation by insulin in fat and muscle cells [41], IRAP translocates to the plasma membrane, presenting its catalytic domain to the extracellular surface.
Localization (translocates) of IRAP in fat
6) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

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