INT255994

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.21
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ang, Il1rn) extracellular region (Ang, Il1rn) nucleus (Ang, Il1rn)
cell differentiation (Ang) lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
brain 1
Ang (Mus musculus)
Il1rn (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 3 92.60 High High
long-term potentiation 6 92.32 High High
Hippocampus 6 92.20 High High
Eae 3 91.36 High High
alcohol 3 82.60 Quite High
ischemia 3 77.80 Quite High
nMDA receptor antagonist 3 15.16 Low Low
agonist 6 11.20 Low Low
Potency 9 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 15 98.96 Very High Very High Very High
Cognitive Disorder 27 91.36 High High
Cv Unclassified Under Development 3 77.80 Quite High
Brain Injury 3 46.20 Quite Low
Disease 45 28.88 Quite Low
Death 3 17.72 Low Low
Obesity 3 6.88 Low Low
Alzheimer's Dementia 9 5.00 Very Low Very Low Very Low
Neurological Disease 6 5.00 Very Low Very Low Very Low
Amnesia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies on the global IRAP knockout mouse revealed an important proof-of-concept: that IRAP is the specific binding site in the brain for the peptide IRAP inhibitors, Ang IV and LVV-H7.
Ang Binding (binding) of IRAP in brain associated with targeted disruption
1) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.42 Pain Relevance 0.24
Although the mechanism via which Ang IV and LVV-H7, by binding to IRAP, facilitate memory acquisition and retrieval is not fully understood, it is irrefutable that these peptides enhance memory and are specific, high affinity inhibitors of IRAP.
Ang Binding (binding) of IRAP
2) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.49 Pain Relevance 0.11
In 2001, the specific target for Ang IV and LVV-H7 was identified – these peptides bind specifically, and with high affinity, to the transmembrane aminopeptidase IRAP [19].
Ang Binding (bind) of IRAP
3) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.30 Pain Relevance 0.28

General Comments

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