INT256

Context Info Confidence 0.78 First Reported 1977 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 11 Total Number 13 Disease Relevance 2.91 Pain Relevance 6.85

cell proliferation (ADRA1D) plasma membrane (ADRA1D) cell-cell signaling (ADRA1D) DNA metabolic process (ADRA1D) signal transducer activity (ADRA1D)

Anatomy Link Frequency neurons 3 thoracic ducts 1 arm 1 astrocytes 1 ADRA1D (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 33 100.00 qutenza 24 100.00 Neuropeptide 3 99.84 dorsal root ganglion 15 99.72 substance P 21 98.22 antagonist 21 97.50 corticosteroid 1 96.40 Clonidine 16 95.12 Glutamate 6 92.40 adenocard 2 90.96

Disease Link Frequency Relevance Heat Ganglion Cysts 18 99.72 Pressure And Volume Under Development 2 98.66 Purpura 4 98.18 Increased Venous Pressure Under Development 1 94.04 Hypolipidemia 1 92.04 Hemorrhage 1 91.36 Neurogenic Inflammation 3 90.56 Abdominal Pain 1 90.16 Shock 4 88.16 Protein-losing Enteropathies 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We report a 14-year-old boy with classical features of HSP manifestated with edema due to severe intestinal protein loss, measured by elevated fecal alpha 1 antitrypsin secretion.

Localization (cretion. ) of alpha 1 associated with pressure and volume under development and purpura

1) Confidence 0.78 Published 1991 Journal Acta Paediatr Scand Section Abstract Doc Link 2058402 Disease Relevance 0.89 Pain Relevance 0.14

To assess renal tubular function the urinary excretion of alpha 1-microglobulin, N-acetyl-beta-glucosaminidase and Tamm-Horsfall protein were determined before, immediately, and 12 and 24 hours after ESWL.

Localization (excretion) of alpha 1

2) Confidence 0.78 Published 1993 Journal J. Urol. Section Abstract Doc Link 7685425 Disease Relevance 0.30 Pain Relevance 0.09

To characterize the effects of acute administration of selective alpha adrenoreceptor agonists or antagonists on capsaicin-evoked substance P (SP) release from dorsal root ganglion (DRG) neurons, dissociated cultured DRG neurons were preincubated with selective alpha 1-adrenoreceptor agonist phenylephrine (10(-5) mol/L), alpha 1-adrenoreceptor antagonist prazosin (10(-6) mol/L), alpha 2-adrenoreceptor agonist clonidine (10(-5) mol/L), alpha 2-adrenoreceptor antagonist yohimbine (10(-5) mol/L) for 10 min, followed by the addition of capsaicin (10(-7) nmol/L) for additional 10 min.

Localization (preincubated) of alpha 1 in neurons associated with ganglion cysts, dorsal root ganglion, qutenza, antagonist, agonist, clonidine and substance p

3) Confidence 0.73 Published 2010 Journal Pharmazie Section Abstract Doc Link 20187578 Disease Relevance 0.46 Pain Relevance 1.33

These results suggest that both alpha-1 and alpha-2 adrenoceptors are located on the lymphatic smooth muscles of canine thoracic ducts.

Localization (located) of alpha-1 in thoracic ducts

4) Confidence 0.73 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2164089 Disease Relevance 0.09 Pain Relevance 0.25

To characterize the effects of acute administration of selective alpha adrenoreceptor agonists or antagonists on capsaicin-evoked substance P (SP) release from dorsal root ganglion (DRG) neurons, dissociated cultured DRG neurons were preincubated with selective alpha 1-adrenoreceptor agonist phenylephrine (10(-5) mol/L), alpha 1-adrenoreceptor antagonist prazosin (10(-6) mol/L), alpha 2-adrenoreceptor agonist clonidine (10(-5) mol/L), alpha 2-adrenoreceptor antagonist yohimbine (10(-5) mol/L) for 10 min, followed by the addition of capsaicin (10(-7) nmol/L) for additional 10 min.

Localization (selective) of alpha 1 in neurons associated with ganglion cysts, dorsal root ganglion, qutenza, antagonist, agonist, clonidine and substance p

5) Confidence 0.73 Published 2010 Journal Pharmazie Section Abstract Doc Link 20187578 Disease Relevance 0.46 Pain Relevance 1.32

The data provided in the present study suggest that the excitatory effect of alpha 1-adrenoreceptor agonist on capsaicin-evoked release of neuropeptide from primary cultured DRG neurons is likely to be mediated by activation of VR1 to influence capsaicin sensitivity but not by promotion of SP synthesis under acute stimulative states.

Localization (release) of alpha 1 in neurons associated with dorsal root ganglion, qutenza, neuropeptide, agonist and substance p

6) Confidence 0.73 Published 2010 Journal Pharmazie Section Abstract Doc Link 20187578 Disease Relevance 0.51 Pain Relevance 1.74

Adrenergic responses were mediated by alpha 1-receptors localized to astrocytes because PE and NE increased [Ca2+]i of acutely isolated hippocampal astrocytes.

Localization (localized) of alpha 1 in astrocytes

7) Confidence 0.73 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7643199 Disease Relevance 0 Pain Relevance 0.46

Sensitization of human alpha 1- and alpha 2-adrenergic venous responses by guanadrel sulfate.

Localization (Sensitization) of alpha 1

8) Confidence 0.67 Published 1990 Journal Clin. Pharmacol. Ther. Section Title Doc Link 2171846 Disease Relevance 0.06 Pain Relevance 0.35

Availability of this radioligand should facilitate the localization and biochemical characterization of this alpha-adrenergic receptor subtype.

Localization (localization) of alpha-adrenergic receptor

9) Confidence 0.45 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3005829 Disease Relevance 0 Pain Relevance 0.21

The effect of BS 100-141, N-amidino 2-(2.6 dichlorophenyl) acetamide hydrochloride, a new drug with central alpha-adrenoceptor activity, on growth hormone (GH) secretion was investigated in 24 young, healthy volunteers.

Localization (secretion) of alpha-adrenoceptor

10) Confidence 0.28 Published 1977 Journal Metab. Clin. Exp. Section Abstract Doc Link 20551 Disease Relevance 0 Pain Relevance 0.14

Other adrenergic agonists capable of activating alpha-2 adrenoceptors (e.g., epinephrine, norepinephrine and xylazine) also significantly depressed 3H-NE secretion, whereas selective alpha-1 adrenergic or beta adrenergic agonists were without effect.

Localization (secretion) of alpha-1 associated with agonist

11) Confidence 0.26 Published 1987 Journal Curr. Eye Res. Section Abstract Doc Link 3038473 Disease Relevance 0.13 Pain Relevance 0.56

Retrospective analysis of the saturation experiments demonstrated that Bmax can be accurately calculated by determining specific [125I]-Heat binding at a single ligand concentration. [125I]-Heat is an ideal ligand for studying alpha 1 adrenergic receptors in the prostate and its favorable properties should facilitate the autoradiographic localization of alpha 1 adrenergic receptors in the prostate.

Localization (localization) of alpha 1

12) Confidence 0.20 Published 1987 Journal J. Urol. Section Abstract Doc Link 2822972 Disease Relevance 0 Pain Relevance 0.09

Three HPLC fractions were isolated for receptor binding studies with monobiotinylation of Lys-9 (B1 beta and B1X beta; X = C6 spacer arm), Lys-19 (B1 gamma), and a mixture of Lys-24, Lys-28, and Lys-29 derivatives (B1 alpha, BX1 alpha).

Localization (monobiotinylation) of BX1 alpha in arm

13) Confidence 0.03 Published 1988 Journal J. Biol. Chem. Section Abstract Doc Link 2826453 Disease Relevance 0 Pain Relevance 0.17

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