INT256

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Context Info
Confidence 0.78
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 2.91
Pain Relevance 6.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ADRA1D) plasma membrane (ADRA1D) cell-cell signaling (ADRA1D)
DNA metabolic process (ADRA1D) signal transducer activity (ADRA1D)
Anatomy Link Frequency
neurons 3
thoracic ducts 1
arm 1
astrocytes 1
ADRA1D (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 33 100.00 Very High Very High Very High
qutenza 24 100.00 Very High Very High Very High
Neuropeptide 3 99.84 Very High Very High Very High
dorsal root ganglion 15 99.72 Very High Very High Very High
substance P 21 98.22 Very High Very High Very High
antagonist 21 97.50 Very High Very High Very High
corticosteroid 1 96.40 Very High Very High Very High
Clonidine 16 95.12 Very High Very High Very High
Glutamate 6 92.40 High High
adenocard 2 90.96 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 18 99.72 Very High Very High Very High
Pressure And Volume Under Development 2 98.66 Very High Very High Very High
Purpura 4 98.18 Very High Very High Very High
Increased Venous Pressure Under Development 1 94.04 High High
Hypolipidemia 1 92.04 High High
Hemorrhage 1 91.36 High High
Neurogenic Inflammation 3 90.56 High High
Abdominal Pain 1 90.16 High High
Shock 4 88.16 High High
Protein-losing Enteropathies 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report a 14-year-old boy with classical features of HSP manifestated with edema due to severe intestinal protein loss, measured by elevated fecal alpha 1 antitrypsin secretion.
Localization (cretion. ) of alpha 1 associated with pressure and volume under development and purpura
1) Confidence 0.78 Published 1991 Journal Acta Paediatr Scand Section Abstract Doc Link 2058402 Disease Relevance 0.89 Pain Relevance 0.14
To assess renal tubular function the urinary excretion of alpha 1-microglobulin, N-acetyl-beta-glucosaminidase and Tamm-Horsfall protein were determined before, immediately, and 12 and 24 hours after ESWL.
Localization (excretion) of alpha 1
2) Confidence 0.78 Published 1993 Journal J. Urol. Section Abstract Doc Link 7685425 Disease Relevance 0.30 Pain Relevance 0.09
To characterize the effects of acute administration of selective alpha adrenoreceptor agonists or antagonists on capsaicin-evoked substance P (SP) release from dorsal root ganglion (DRG) neurons, dissociated cultured DRG neurons were preincubated with selective alpha 1-adrenoreceptor agonist phenylephrine (10(-5) mol/L), alpha 1-adrenoreceptor antagonist prazosin (10(-6) mol/L), alpha 2-adrenoreceptor agonist clonidine (10(-5) mol/L), alpha 2-adrenoreceptor antagonist yohimbine (10(-5) mol/L) for 10 min, followed by the addition of capsaicin (10(-7) nmol/L) for additional 10 min.
Localization (preincubated) of alpha 1 in neurons associated with ganglion cysts, dorsal root ganglion, qutenza, antagonist, agonist, clonidine and substance p
3) Confidence 0.73 Published 2010 Journal Pharmazie Section Abstract Doc Link 20187578 Disease Relevance 0.46 Pain Relevance 1.33
These results suggest that both alpha-1 and alpha-2 adrenoceptors are located on the lymphatic smooth muscles of canine thoracic ducts.
Localization (located) of alpha-1 in thoracic ducts
4) Confidence 0.73 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2164089 Disease Relevance 0.09 Pain Relevance 0.25
To characterize the effects of acute administration of selective alpha adrenoreceptor agonists or antagonists on capsaicin-evoked substance P (SP) release from dorsal root ganglion (DRG) neurons, dissociated cultured DRG neurons were preincubated with selective alpha 1-adrenoreceptor agonist phenylephrine (10(-5) mol/L), alpha 1-adrenoreceptor antagonist prazosin (10(-6) mol/L), alpha 2-adrenoreceptor agonist clonidine (10(-5) mol/L), alpha 2-adrenoreceptor antagonist yohimbine (10(-5) mol/L) for 10 min, followed by the addition of capsaicin (10(-7) nmol/L) for additional 10 min.
Localization (selective) of alpha 1 in neurons associated with ganglion cysts, dorsal root ganglion, qutenza, antagonist, agonist, clonidine and substance p
5) Confidence 0.73 Published 2010 Journal Pharmazie Section Abstract Doc Link 20187578 Disease Relevance 0.46 Pain Relevance 1.32
The data provided in the present study suggest that the excitatory effect of alpha 1-adrenoreceptor agonist on capsaicin-evoked release of neuropeptide from primary cultured DRG neurons is likely to be mediated by activation of VR1 to influence capsaicin sensitivity but not by promotion of SP synthesis under acute stimulative states.
Localization (release) of alpha 1 in neurons associated with dorsal root ganglion, qutenza, neuropeptide, agonist and substance p
6) Confidence 0.73 Published 2010 Journal Pharmazie Section Abstract Doc Link 20187578 Disease Relevance 0.51 Pain Relevance 1.74
Adrenergic responses were mediated by alpha 1-receptors localized to astrocytes because PE and NE increased [Ca2+]i of acutely isolated hippocampal astrocytes.
Localization (localized) of alpha 1 in astrocytes
7) Confidence 0.73 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7643199 Disease Relevance 0 Pain Relevance 0.46
Sensitization of human alpha 1- and alpha 2-adrenergic venous responses by guanadrel sulfate.
Localization (Sensitization) of alpha 1
8) Confidence 0.67 Published 1990 Journal Clin. Pharmacol. Ther. Section Title Doc Link 2171846 Disease Relevance 0.06 Pain Relevance 0.35
Availability of this radioligand should facilitate the localization and biochemical characterization of this alpha-adrenergic receptor subtype.
Localization (localization) of alpha-adrenergic receptor
9) Confidence 0.45 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3005829 Disease Relevance 0 Pain Relevance 0.21
The effect of BS 100-141, N-amidino 2-(2.6 dichlorophenyl) acetamide hydrochloride, a new drug with central alpha-adrenoceptor activity, on growth hormone (GH) secretion was investigated in 24 young, healthy volunteers.
Localization (secretion) of alpha-adrenoceptor
10) Confidence 0.28 Published 1977 Journal Metab. Clin. Exp. Section Abstract Doc Link 20551 Disease Relevance 0 Pain Relevance 0.14
Other adrenergic agonists capable of activating alpha-2 adrenoceptors (e.g., epinephrine, norepinephrine and xylazine) also significantly depressed 3H-NE secretion, whereas selective alpha-1 adrenergic or beta adrenergic agonists were without effect.
Localization (secretion) of alpha-1 associated with agonist
11) Confidence 0.26 Published 1987 Journal Curr. Eye Res. Section Abstract Doc Link 3038473 Disease Relevance 0.13 Pain Relevance 0.56
Retrospective analysis of the saturation experiments demonstrated that Bmax can be accurately calculated by determining specific [125I]-Heat binding at a single ligand concentration. [125I]-Heat is an ideal ligand for studying alpha 1 adrenergic receptors in the prostate and its favorable properties should facilitate the autoradiographic localization of alpha 1 adrenergic receptors in the prostate.
Localization (localization) of alpha 1
12) Confidence 0.20 Published 1987 Journal J. Urol. Section Abstract Doc Link 2822972 Disease Relevance 0 Pain Relevance 0.09
Three HPLC fractions were isolated for receptor binding studies with monobiotinylation of Lys-9 (B1 beta and B1X beta; X = C6 spacer arm), Lys-19 (B1 gamma), and a mixture of Lys-24, Lys-28, and Lys-29 derivatives (B1 alpha, BX1 alpha).
Localization (monobiotinylation) of BX1 alpha in arm
13) Confidence 0.03 Published 1988 Journal J. Biol. Chem. Section Abstract Doc Link 2826453 Disease Relevance 0 Pain Relevance 0.17

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