INT256005

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.97
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Lnpep) plasma membrane (Lnpep) intracellular (Lnpep)
cytoplasm (Lnpep)
Lnpep (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 6 77.12 Quite High
antagonist 18 69.16 Quite High
Enkephalin 3 60.24 Quite High
Onset of action 3 10.32 Low Low
Hippocampus 9 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
Thalamus 6 5.00 Very Low Very Low Very Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
Locus ceruleus 3 5.00 Very Low Very Low Very Low
beta blocker 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 93 98.78 Very High Very High Very High
Obesity 3 92.12 High High
Sprains And Strains 24 88.00 High High
Targeted Disruption 6 42.80 Quite Low
Hypertension 12 5.00 Very Low Very Low Very Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Myocardial Infarction 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the presence of insulin, IRAP and GLUT4 translocate to the cell membrane where GLUT4 mediates glucose uptake.
Localization (translocate) of IRAP
1) Confidence 0.66 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.09 Pain Relevance 0.06
Our work, in combination with that of others, suggests that it is the peptide metabolites of oxytocin that are responsible for the enhanced cognition, and that angiotensin IV prevents its effects by inhibiting IRAP (oxytocinase) and the metabolism of oxytocin.
Localization (metabolism) of oxytocinase associated with cognitive disorder
2) Confidence 0.62 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.44 Pain Relevance 0.07
Our work, in combination with that of others, suggests that it is the peptide metabolites of oxytocin that are responsible for the enhanced cognition, and that angiotensin IV prevents its effects by inhibiting IRAP (oxytocinase) and the metabolism of oxytocin.
Localization (metabolism) of IRAP associated with cognitive disorder
3) Confidence 0.62 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.44 Pain Relevance 0.07

General Comments

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