INT256019

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.76
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Lnpep) extracellular space (Agt) plasma membrane (Lnpep)
intracellular (Lnpep) extracellular matrix organization (Agt) cytoplasm (Lnpep)
Anatomy Link Frequency
brain 1
Agt (Mus musculus)
Lnpep (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 12 93.80 High High
Enkephalin 6 91.92 High High
antagonist 36 85.84 High High
Onset of action 6 69.92 Quite High
Hippocampus 18 5.00 Very Low Very Low Very Low
Dopamine 12 5.00 Very Low Very Low Very Low
Thalamus 12 5.00 Very Low Very Low Very Low
long-term potentiation 6 5.00 Very Low Very Low Very Low
Locus ceruleus 6 5.00 Very Low Very Low Very Low
beta blocker 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 186 99.78 Very High Very High Very High
Sprains And Strains 48 86.40 High High
Obesity 6 83.76 Quite High
Targeted Disruption 12 59.48 Quite High
Anxiety Disorder 12 6.12 Low Low
Hypertension 24 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Myocardial Infarction 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GLUT4 has been identified in the brain in regions associated with AT4 receptors and it has been speculated by Albiston that inhibition of IRAP by angiotensin IV might increase glucose uptake into brain cells resulting in facilitation of learning and memory.
angiotensin IV Negative_regulation (inhibition) of IRAP in brain
1) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.08 Pain Relevance 0.08
Our work, in combination with that of others, suggests that it is the peptide metabolites of oxytocin that are responsible for the enhanced cognition, and that angiotensin IV prevents its effects by inhibiting IRAP (oxytocinase) and the metabolism of oxytocin.
angiotensin IV Negative_regulation (inhibiting) of IRAP associated with cognitive disorder
2) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.43 Pain Relevance 0.08
These results may be interpreted as an indication that by inhibiting IRAP (oxytocinase), angiotensin IV increases endogenous oxytocin to concentrations in the amnesic range, or that angiotensin IV blocks the behavioural effects of oxytocin by some other mechanism.
angiotensin IV Negative_regulation (inhibiting) of oxytocinase
3) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.31 Pain Relevance 0.09
Some of these peptides, for example, oxytocin and vasopressin, have been implicated in learning and memory, and it also has been suggested by Albiston et al. [21], that inhibition of IRAP by angiotensin IV results in the accumulation of these peptides that enhance memory.
angiotensin IV Negative_regulation (inhibition) of IRAP
4) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.21 Pain Relevance 0.13
Our work, in combination with that of others, suggests that it is the peptide metabolites of oxytocin that are responsible for the enhanced cognition, and that angiotensin IV prevents its effects by inhibiting IRAP (oxytocinase) and the metabolism of oxytocin.
angiotensin IV Negative_regulation (inhibiting) of oxytocinase associated with cognitive disorder
5) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.43 Pain Relevance 0.08
These results may be interpreted as an indication that by inhibiting IRAP (oxytocinase), angiotensin IV increases endogenous oxytocin to concentrations in the amnesic range, or that angiotensin IV blocks the behavioural effects of oxytocin by some other mechanism.
angiotensin IV Negative_regulation (inhibiting) of IRAP
6) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.31 Pain Relevance 0.09

General Comments

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