INT25602

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.55
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (THPO) extracellular space (THPO) extracellular region (THPO)
Anatomy Link Frequency
precursor cells 1
granulocyte 1
THPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 5 96.84 Very High Very High Very High
cytokine 12 90.48 High High
Bioavailability 3 90.00 High High
agonist 3 86.88 High High
Pain 2 72.76 Quite High
cINOD 1 72.56 Quite High
headache 8 72.24 Quite High
corticosteroid 26 27.16 Quite Low
fibrosis 15 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukocytosis 9 99.54 Very High Very High Very High
Cancer 37 99.04 Very High Very High Very High
Syndrome 215 97.76 Very High Very High Very High
Cholangiocarcinoma 1 95.36 Very High Very High Very High
Toxicity 4 93.68 High High
Thrombocytopenia 144 90.48 High High
Hypercalcemia 7 88.84 High High
Malignant Neoplastic Disease 45 88.64 High High
Purpura 6 88.48 High High
Skin Diseases 59 82.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It activates TPO receptor with kinetics similar to rhTPO resulting in proliferation of TPO-dependent cell lines and induces the differentiation of bone marrow precursor cells.
Positive_regulation (activates) of TPO receptor in precursor cells
1) Confidence 0.69 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915538 Disease Relevance 0 Pain Relevance 0.08
Each class has a unique structure and therefore a unique mode of activation of the TPO receptor.
Positive_regulation (activation) of TPO receptor
2) Confidence 0.69 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915538 Disease Relevance 0.26 Pain Relevance 0.07
Eltrombopag is a TPO nonpeptide mimetic administered orally that activates the TPO receptor by binding to the transmembrane domain.
Positive_regulation (activates) of TPO
3) Confidence 0.50 Published 2009 Journal Annu. Rev. Med. Section Abstract Doc Link 19642221 Disease Relevance 0.62 Pain Relevance 0.07
Eltrombopag was first developed by Duffy et al following the screening of libraries of small molecules using an assay to identify structures that stimulate the TPO receptor-linked transduction pathways.32,33 The libraries of small compounds underwent further biological modification prior to entering clinical trials with the sulfonate group being replaced by a biphenyl carboxylate compound in order to yield higher oral bioavailability.34
Positive_regulation (stimulate) of TPO receptor associated with bioavailability
4) Confidence 0.50 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915538 Disease Relevance 0.12 Pain Relevance 0.08
Leukocytosis was attributed to the elevated colony-stimulating factor activity which was two-fold of control.
Positive_regulation (elevated) of colony-stimulating factor associated with leukocytosis
5) Confidence 0.08 Published 1989 Journal Jpn. J. Med. Section Abstract Doc Link 2534486 Disease Relevance 1.59 Pain Relevance 0.07
Interferon-gamma, interleukin-6 and colony stimulating factor concentrations in sera of indomethacin/beta-glucan-treated mice were significantly elevated.
Positive_regulation (elevated) of colony stimulating factor
6) Confidence 0.08 Published 1998 Journal FEMS Immunol. Med. Microbiol. Section Abstract Doc Link 9718206 Disease Relevance 0.48 Pain Relevance 0.12
Although the level of serum granuocyte-colony stimulating factor was not abnormally elevated, the detection of granulocyte-colony stimulating factor in the tumor suggests the possiblity that tumors capable of producing granulocyte-colony stimulating factor might cause Sweet's syndrome in these oncology patients [397].
Neg (not) Positive_regulation (elevated) of serum granuocyte-colony stimulating factor in granulocyte associated with syndrome and cancer
7) Confidence 0.06 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1963326 Disease Relevance 1.48 Pain Relevance 0.07

General Comments

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