INT256028

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.16
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Lnpep) extracellular space (Agt) plasma membrane (Lnpep)
intracellular (Lnpep) extracellular matrix organization (Agt) cytoplasm (Lnpep)
Agt (Mus musculus)
Lnpep (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 24 90.76 High High
Onset of action 4 72.76 Quite High
long-term potentiation 4 65.12 Quite High
Hippocampus 12 60.56 Quite High
Eae 8 58.80 Quite High
Dopamine 8 54.16 Quite High
antidepressant 4 48.68 Quite Low
Enkephalin 4 47.60 Quite Low
Thalamus 8 34.16 Quite Low
Locus ceruleus 4 23.28 Low Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 124 93.12 High High
Targeted Disruption 8 89.36 High High
Sprains And Strains 32 75.72 Quite High
Anxiety Disorder 8 58.92 Quite High
Obesity 4 51.04 Quite High
Hypertension 16 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Myocardial Infarction 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The remainder of this review will concentrate on the possible interaction of angiotensin IV, IRAP, also known as oxytocinase and oxytocin.
angiotensin IV Binding (interaction) of oxytocinase
1) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.64 Pain Relevance 0
The compromise suggested by Wright and Harding [6] is that angiotensin IV binds to IRAP, its cognate receptor, but that there is some other transduction mechanism not reliant on inhibition of the enzyme.
angiotensin IV Binding (binds) of IRAP
2) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.19 Pain Relevance 0.17
To summarise the argument: the AT4 receptor and IRAP have identical binding properties for angiotensin IV, and expression of the cDNA for IRAP gives rise to a protein with the binding characteristics of the AT4 receptor.
angiotensin IV Binding (properties) of IRAP
3) Confidence 0.15 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.05 Pain Relevance 0
If angiotensin IV produces its effects via interaction with IRAP and oxytocin, a similar pattern of effects might therefore be seen.
angiotensin IV Binding (interaction) of IRAP
4) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.28 Pain Relevance 0.07

General Comments

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