INT256035

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.23
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sumo1) transcription factor binding (Sumo1) response to stress (Sumo1)
cytoplasm (Sumo1)
Sumo1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1 91.36 High High
Nerve growth factor 55 80.96 Quite High
agonist 5 70.40 Quite High
Serotonin 2 69.44 Quite High
antidepressant 1 63.12 Quite High
sSRI 1 60.12 Quite High
peripheral neuropathy 1 54.28 Quite High
Hippocampus 5 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Intracerebroventricular 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 112 98.64 Very High Very High Very High
Disease 37 93.32 High High
Cognitive Disorder 3 75.16 Quite High
Neuropathic Pain 1 73.16 Quite High
Disease Progression 2 64.52 Quite High
Myeloproliferative Disorder 44 63.72 Quite High
Leukemia 34 54.36 Quite High
Peripheral Neuropathy 2 54.28 Quite High
Hematologic Neoplasms 4 53.36 Quite High
Attention Deficit Hyperactivity Disorder 1 43.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sorted GMP-L stably engrafted recipients with AML within 2 mo after transfer, and serial dilution experiments demonstrated that as few as 20 GMP-L cells could serially transplant disease and give rise to an expanded GMP-L cell population without evidence of HSC or other normal myeloid progenitor contamination (Fig.
Positive_regulation (Sorted) of GMP-L associated with myeloid leukemia and disease
1) Confidence 0.03 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.79 Pain Relevance 0
Mice transplanted with miR-29a–expressing CMP or GMP possessed donor-derived CMP and GMP, respectively, as well as their differentiated GFP+ progeny (Mac1+Gr-1+ cells), even 2 mo after the transplantation (Fig. 3 e).
Positive_regulation (derived) of GMP
2) Confidence 0.03 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.11 Pain Relevance 0
The protective effect requires cyclic GMP and protein kinase G, but the downstream target is not known.
Positive_regulation (requires) of GMP
3) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.33 Pain Relevance 0.41

General Comments

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