INT256036

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.96
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf5)
Anatomy Link Frequency
nerve 1
Cornu 1
Ntf5 (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 20 100.00 Very High Very High Very High
Nerve growth factor 62 99.80 Very High Very High Very High
Pyramidal cell 5 95.08 Very High Very High Very High
Hippocampus 14 93.60 High High
antidepressant 91 92.24 High High
sSRI 37 83.64 Quite High
Serotonin 25 80.40 Quite High
nMDA receptor 15 76.16 Quite High
Thalamus 1 73.36 Quite High
dexamethasone 1 63.12 Quite High
Disease Link Frequency Relevance Heat
Aging 5 98.60 Very High Very High Very High
Injury 9 98.04 Very High Very High Very High
Targeted Disruption 18 97.28 Very High Very High Very High
Depression 72 89.24 High High
Brain Injury 5 87.52 High High
Disease 118 83.88 Quite High
Cognitive Disorder 23 55.12 Quite High
Death 13 45.44 Quite Low
Spinal Cord Injury 3 36.48 Quite Low
Alzheimer's Dementia 38 13.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is a family of structurally related trophic factors that includes BDNF, neurotrophin-3, neurotrophin-4 and nerve growth factor (NGF).
Positive_regulation (includes) of neurotrophin-4 in nerve associated with nerve growth factor and bdmf
1) Confidence 0.04 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2845130 Disease Relevance 0.62 Pain Relevance 0.77
Cortical and hippocampal NT-4/5 levels are elevated in rats subjected to a lateral fluid percussion injury, and NT-4/5 knockout mice showed more extensive Cornu Ammonis (CA) pyramidal cell loss and showed impaired motor recovery compared to wild-type mice Prolonged infusion of NT-4/5 prevented 50% of the pyramidal cell loss.
Positive_regulation (elevated) of NT-4 in Cornu associated with targeted disruption, pyramidal cell and injury
2) Confidence 0.03 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 1.35 Pain Relevance 0.38

General Comments

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