INT256040

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) signal transduction (Ngf) extracellular space (Ngf)
extracellular region (Ngf) plasma membrane (Ntrk1) kinase activity (Ntrk1)
Anatomy Link Frequency
neuronal 2
Ngf (Mus musculus)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 55 100.00 Very High Very High Very High
Intracerebroventricular 3 63.84 Quite High
Hippocampus 5 40.88 Quite Low
long-term potentiation 2 20.32 Low Low
Spinal cord 4 19.84 Low Low
agonist 5 5.00 Very Low Very Low Very Low
Pyramidal cell 3 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 4 99.12 Very High Very High Very High
Disease 21 96.76 Very High Very High Very High
Death 8 95.80 Very High Very High Very High
Targeted Disruption 8 86.80 High High
Confusion 1 64.88 Quite High
Amnesia 1 58.92 Quite High
Convulsion 2 29.88 Quite Low
Spinal Cord Injury 3 20.20 Low Low
Neurodegenerative Disease 2 18.68 Low Low
Cognitive Disorder 3 12.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction in TrkA suggests a relative deficit in NGF signaling, as NGF positively regulates trkA gene expression. proNGF may increase apoptotic signaling via p75NTR, altering the balance between neuronal survival and death.
NGF Regulation (regulates) of Gene_expression (expression) of trkA in neuronal associated with nerve growth factor, apoptosis and death
1) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.73 Pain Relevance 0.50

General Comments

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