INT256041

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.90
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ngfr, Ntrk1) cytoplasm (Ngfr, Ntrk1) cell differentiation (Ntrk1)
signal transduction (Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
Ngfr (Mus musculus)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 158 100.00 Very High Very High Very High
intrathecal 1 89.76 High High
Spinal cord 13 88.00 High High
agonist 10 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
Intracerebroventricular 6 5.00 Very Low Very Low Very Low
Peripheral nervous system 6 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
long-term potentiation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Death 18 97.92 Very High Very High Very High
Frailty 2 88.28 High High
Injury 63 74.00 Quite High
Brain Injury 57 65.72 Quite High
Middle Cerebral Artery Infarction 4 48.88 Quite Low
Targeted Disruption 17 28.96 Quite Low
Diffuse Axonal Injury 8 19.40 Low Low
Disease 42 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All neurotrophins bind p75NTR with similar affinity (Kd~10-9 M), but binding to the Trk receptors is more selective.
p75NTR Binding (binding) of Trk
1) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.17 Pain Relevance 0.27
The neurotrophins bind two classes of receptor, the common p75NTR, which is a member of the tumor necrosis factor receptor family [2,3], and the tropomyosin-related kinase (Trk) receptors, members of the large tyrosine kinase receptor family [4].
p75NTR Binding (bind) of Trk associated with necrosis and cancer
2) Confidence 0.12 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.20 Pain Relevance 0.16
In the absence of trkA, NGF binds to its low affinity receptor p75NTR, which is thought to be responsible for triggering death pathways [47].
p75NTR Binding (binds) of trkA associated with nerve growth factor and death
3) Confidence 0.06 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.53 Pain Relevance 0.70

General Comments

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