INT256044

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ngfr, Ntrk1) signal transduction (Ngfr, Ngf) plasma membrane (Ngfr, Ntrk1)
cell differentiation (Ntrk1) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
Ngfr (Mus musculus)
Ngf (Mus musculus)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 55 100.00 Very High Very High Very High
Hippocampus 5 35.36 Quite Low
Intracerebroventricular 3 32.08 Quite Low
agonist 5 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Pyramidal cell 3 5.00 Very Low Very Low Very Low
long-term potentiation 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 8 80.56 Quite High
Necrosis 1 69.00 Quite High
Cancer 1 68.64 Quite High
Targeted Disruption 8 52.00 Quite High
Disease 21 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low
Brain Injury 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The common p75NTR also enhances binding of NGF to TrkA receptors to create high affinity binding sites (Kd~10-11 M), possibly by binding to different surfaces on the NGF dimer [6]. p75NTR can also bind precursor forms of the neurotrophins.
p75NTR Spec (possibly) Positive_regulation (enhances) of NGF Binding (binding) of TrkA associated with nerve growth factor
1) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.27 Pain Relevance 0.30

General Comments

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