INT256045

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.65
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) extracellular region (BDNF) plasma membrane (Ntrk1)
cytoplasmic membrane-bounded vesicle (BDNF) kinase activity (Ntrk1) cytoplasm (Ntrk1)
BDNF (Homo sapiens)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 118 100.00 Very High Very High Very High
Central nervous system 12 59.80 Quite High
depression 146 50.00 Quite Low
long-term potentiation 8 29.88 Quite Low
Hippocampus 96 13.40 Low Low
antidepressant 126 5.00 Very Low Very Low Very Low
fluoxetine 38 5.00 Very Low Very Low Very Low
Desipramine 20 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Congenital Anomalies 18 83.12 Quite High
Hyperplasia 2 54.28 Quite High
Depression 190 50.00 Quite Low
Death 24 48.88 Quite Low
Suicidal Behaviour 246 34.16 Quite Low
Mental Disorders 12 28.32 Quite Low
Stress 52 23.40 Low Low
Targeted Disruption 28 20.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neurotrophins bind two classes of receptor, the common p75NTR, which is a member of the tumor necrosis factor receptor family [2,3], and the tropomyosin-related kinase (Trk) receptors, members of the large tyrosine kinase receptor family [4].
neurotrophin Binding (bind) of Trk associated with necrosis and cancer
1) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.20 Pain Relevance 0.16
All neurotrophins bind p75NTR with similar affinity (Kd~10-9 M), but binding to the Trk receptors is more selective.
neurotrophin Binding (binding) of Trk
2) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.17 Pain Relevance 0.27
The interaction of neurotrophins with the Trk receptors is specific: NGF binds with TrkA, BDNF and NT 4 both bind with TrkB, and NT 3 binds with the highest affinity to TrkC but is also capable of signaling through TrkA and TrkB.
neurotrophin Binding (interaction) of Trk associated with nerve growth factor
3) Confidence 0.05 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.14 Pain Relevance 0.20
The interaction of neurotrophins with the Trk receptors is specific: NGF binds with TrkA, BDNF and NT 4 both bind with TrkB, and NT 3 binds with the highest affinity to TrkC but is also capable of signaling through TrkA and TrkB.
neurotrophin Binding (binds) of TrkA associated with nerve growth factor
4) Confidence 0.05 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.14 Pain Relevance 0.20

General Comments

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