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Context Info
Confidence 0.85
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.44
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
extracellular matrix 3
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 60 100.00 Very High Very High Very High
fibrosis 38 77.28 Quite High
Inflammation 60 76.64 Quite High
cytokine 24 73.68 Quite High
chemokine 12 72.56 Quite High
Inflammatory response 22 66.12 Quite High
agonist 1 59.24 Quite High
Bioavailability 1 41.44 Quite Low
ischemia 3 38.32 Quite Low
Mechanotransduction 6 26.20 Quite Low
Disease Link Frequency Relevance Heat
Cancer 161 99.40 Very High Very High Very High
Metastasis 34 97.12 Very High Very High Very High
Fibrosis 51 95.96 Very High Very High Very High
Apoptosis 10 87.92 High High
Vasculitis 8 85.00 Quite High
Hypertension 1 84.20 Quite High
Stress 15 78.32 Quite High
INFLAMMATION 74 70.08 Quite High
Cirrhosis 15 62.88 Quite High
Disease 9 56.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMPs such as MMP-8, MMP-9, and MMP-13 possess the ability to degrade the extracellular matrix by breakdown of fibrillar collagen type I [9], [19], [37].
Protein_catabolism (degrade) of MMP-9 in extracellular matrix associated with metalloproteinase
1) Confidence 0.85 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.82 Pain Relevance 0.15
MMP-2, MMP-9, and uPA are known to be involved in the degradation of extracellular matrix and play a critical role in tumor invasion and metastasis.
Protein_catabolism (degradation) of MMP-9 in extracellular matrix associated with cancer, metalloproteinase and metastasis
2) Confidence 0.09 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 1.03 Pain Relevance 0.36
Other candidate macrophage-derived molecules that may be responsible for structural vascular reorganization include matrix metalloproteinase-9, which is required for extracellular matrix degradation in outward remodeling of mouse carotid arteries (33), and coagulation factor XIII, which is a transglutaminase associated with extracellular matrix cross-linking during inward remodeling of mouse mesenteric arteries (54).
Protein_catabolism (degradation) of metalloproteinase-9 in extracellular matrix associated with metalloproteinase
3) Confidence 0.06 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.59 Pain Relevance 0.29

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