INT256054

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.03
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Txn2) mitochondrion (Txn2) nucleolus (Txn2)
Anatomy Link Frequency
external carotid artery 1
Txn2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 40 98.48 Very High Very High Very High
Inflammatory response 34 96.64 Very High Very High Very High
Inflammation 48 73.88 Quite High
ischemia 13 69.04 Quite High
anesthesia 6 65.60 Quite High
Mechanotransduction 12 56.88 Quite High
chemokine 24 52.00 Quite High
metalloproteinase 4 35.56 Quite Low
Angina 2 19.52 Low Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 9 99.96 Very High Very High Very High
Cancer 2 99.36 Very High Very High Very High
Coronary Heart Disease 4 99.02 Very High Very High Very High
INFLAMMATION 70 96.64 Very High Very High Very High
Sprains And Strains 10 95.44 Very High Very High Very High
Stress 71 88.60 High High
Diabetic Cardiomyopathies 14 86.28 High High
Insulin Resistance 4 84.40 Quite High
Adhesions 10 84.16 Quite High
Diabetes Mellitus 135 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, the observation of diminished cytokine production after external carotid artery ligation in mice with EC-specific overexpression of TXN2 suggests a primary role for the endothelium in flow-mediated, superoxide-dependent inflammatory responses.
Gene_expression (overexpression) of TXN2 in external carotid artery associated with inflammatory response and cytokine
1) Confidence 0.47 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.59 Pain Relevance 0.25
The generation of EC-specific TXN2 transgenic mice has been previously described (55).
Gene_expression (generation) of TXN2 associated with targeted disruption
2) Confidence 0.41 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.79 Pain Relevance 0.22
In vivo administration of the antioxidant tempol (1 mmol/l in drinking water) for a period of 4-weeks to mice rendered insulin-resistant by deficiency of the insulin-sensitive GLUT4 transporter significantly and potently attenuated cardiac hypertrophy in concert with tempol up-regulated ventricular expression of thioredoxin-2 (confirming an antioxidant action) [101].
Gene_expression (expression) of thioredoxin-2 associated with coronary heart disease
3) Confidence 0.06 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2801857 Disease Relevance 1.65 Pain Relevance 0.06

General Comments

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