INT256056

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Myd88) signal transduction (Myd88) plasma membrane (Myd88)
intracellular (Myd88) protein complex (Myd88) cytoplasm (Myd88)
Myd88 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 34 99.40 Very High Very High Very High
Inflammation 40 88.96 High High
Inflammatory mediators 1 73.80 Quite High
chemokine 12 64.52 Quite High
Inflammatory response 17 58.28 Quite High
Mechanotransduction 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vasculitis 8 89.68 High High
INFLAMMATION 51 73.40 Quite High
Cancer 5 70.24 Quite High
Necrosis 2 69.76 Quite High
Thrombosis 2 38.68 Quite Low
Autoimmune Disease 23 22.80 Low Low
Sprains And Strains 7 22.36 Low Low
Systemic Lupus Erythematosus 61 5.00 Very Low Very Low Very Low
Disease 19 5.00 Very Low Very Low Very Low
Stress 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B activation as a link between MyD88 signaling and cytokine synthesis.


Positive_regulation (activation) of MyD88 Binding (link) of associated with cytokine
1) Confidence 0.48 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.22 Pain Relevance 0.26
Kobayashi et al. showed that IRAK-M, which lacks the kinase activity of its counterparts IRAK1 and IRAK4, suppresses the production of proinflammatory cytokines and proposed a model whereby IRAK-M prevents the dissociation of the IRAK1/IRAK4/MyD88 complex to inhibit downstream NF?
Positive_regulation (/) of MyD88 Binding (complex) of associated with cytokine
2) Confidence 0.36 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.14 Pain Relevance 0.09

General Comments

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