INT256068

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hspg2) extracellular region (Hspg2) proteinaceous extracellular matrix (Hspg2)
extracellular matrix organization (Hspg2)
Hspg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 3 25.08 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 78 99.82 Very High Very High Very High
Necrosis 45 94.96 High High
Death 72 83.84 Quite High
Diabetes Mellitus 21 79.16 Quite High
Disease 3 56.16 Quite High
Diabetic Retinopathy 30 52.48 Quite High
Nerve Degeneration 12 51.60 Quite High
Targeted Disruption 3 49.60 Quite Low
Ocular Toxicity (including Many Sub-types) 9 49.36 Quite Low
Eye Disease 3 37.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, our results demonstrate that the protective effect of SERPINA3K is through blocking intracellular calcium overload induced by oxidative stress through inhibition of PLC activation.
Negative_regulation (inhibition) of Positive_regulation (activation) of PLC associated with stress
1) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605247 Disease Relevance 0.30 Pain Relevance 0
It is likely that binding of SERPINA3K triggers the activation of an intracellular signaling pathway, leading to the blockade of PLC activation and calcium overload under oxidative stress.
Negative_regulation (blockade) of Positive_regulation (activation) of PLC associated with stress
2) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605247 Disease Relevance 0.92 Pain Relevance 0
At 15 min, the SERPINA3K treatment prevented the phosphorylation of PLC induced by H2O2 (60% reduction), but did not inhibit the phosphorylation of the ERK or PI3K/AKT kinases, suggesting that SERPINA3K specifically blocks the activation of PLC under oxidative stress (Fig. 6D, F).


Negative_regulation (prevented) of Positive_regulation (induced) of PLC associated with stress
3) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605247 Disease Relevance 0.16 Pain Relevance 0

General Comments

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